Jeff Boissoneault1, Alfredo Sklar2, Robert Prather2, Sara Jo Nixon2. 1. Pain Research and Intervention Center of Excellence, University of Florida, Gainesville, Florida. 2. Department of Psychiatry, University of Florida, Gainesville, Florida.
Abstract
UNLABELLED: ABSTRACT. OBJECTIVE: Despite substantial attention being paid to the health benefits of moderate alcohol intake as a lifestyle, the acute effects of alcohol on psychomotor and working memory function in older adults are poorly understood. METHOD: The effects of low to moderate doses of alcohol on neurobehavioral function were investigated in 39 older (55-70 years; 15 men) and 51 younger (25-35 years; 31 men) social drinkers. Subjects received one of three randomly assigned doses (placebo, .04 g/dl, or .065 g/dl target breath alcohol concentration). After beverage consumption, they completed the Trail Making Test Parts A and B and a working memory task requiring participants to determine whether probe stimuli were novel or had been presented in a preceding set of cue stimuli. Efficiency of working memory task performance was derived from accuracy and reaction time measures. RESULTS:Alcohol was associated with poorer Trail Making Test Part B performance for older subjects. Working memory task results suggested an Age × Dose interaction for performance efficiency, with older but not younger adults demonstrating alcohol-related change. Directionality of change and whether effects on accuracy or reaction time drove the change depended on the novelty of probe stimuli. CONCLUSIONS: This study replicates previous research indicating increased susceptibility of older adults to moderate alcohol-induced psychomotor and set-shifting impairment and suggests such susceptibility extends to working memory performance. Further research using additional tasks and assessing other neuropsychological domains is needed. (J. Stud. Alcohol Drugs, 75, 870-879, 2014).
RCT Entities:
UNLABELLED: ABSTRACT. OBJECTIVE: Despite substantial attention being paid to the health benefits of moderate alcohol intake as a lifestyle, the acute effects of alcohol on psychomotor and working memory function in older adults are poorly understood. METHOD: The effects of low to moderate doses of alcohol on neurobehavioral function were investigated in 39 older (55-70 years; 15 men) and 51 younger (25-35 years; 31 men) social drinkers. Subjects received one of three randomly assigned doses (placebo, .04 g/dl, or .065 g/dl target breath alcohol concentration). After beverage consumption, they completed the Trail Making Test Parts A and B and a working memory task requiring participants to determine whether probe stimuli were novel or had been presented in a preceding set of cue stimuli. Efficiency of working memory task performance was derived from accuracy and reaction time measures. RESULTS:Alcohol was associated with poorer Trail Making Test Part B performance for older subjects. Working memory task results suggested an Age × Dose interaction for performance efficiency, with older but not younger adults demonstrating alcohol-related change. Directionality of change and whether effects on accuracy or reaction time drove the change depended on the novelty of probe stimuli. CONCLUSIONS: This study replicates previous research indicating increased susceptibility of older adults to moderate alcohol-induced psychomotor and set-shifting impairment and suggests such susceptibility extends to working memory performance. Further research using additional tasks and assessing other neuropsychological domains is needed. (J. Stud. Alcohol Drugs, 75, 870-879, 2014).
Authors: Ben Lewis; Jeff Boissoneault; Rebecca Gilbertson; Robert Prather; Sara Jo Nixon Journal: Alcohol Clin Exp Res Date: 2012-12-28 Impact factor: 3.455
Authors: Lindsay M Squeglia; Jeff Boissoneault; Candice E Van Skike; Sara Jo Nixon; Douglas B Matthews Journal: Alcohol Clin Exp Res Date: 2014-08-25 Impact factor: 3.455
Authors: Ben Lewis; Christian C Garcia; Jeff Boissoneault; Julianne L Price; Sara Jo Nixon Journal: J Stud Alcohol Drugs Date: 2019-01 Impact factor: 2.582
Authors: Landrew Sevel; Bethany Stennett; Victor Schneider; Nicholas Bush; Sara Jo Nixon; Michael Robinson; Jeff Boissoneault Journal: Alcohol Clin Exp Res Date: 2020-06-18 Impact factor: 3.455
Authors: Julianne L Price; Ben Lewis; Jeff Boissoneault; Ian R Frazier; Sara Jo Nixon Journal: Psychopharmacology (Berl) Date: 2017-12-06 Impact factor: 4.530
Authors: Nina Pocuca; T Jordan Walter; Arpi Minassian; Jared W Young; Mark A Geyer; William Perry Journal: Arch Clin Neuropsychol Date: 2021-07-19 Impact factor: 2.813