Sefa Resim1, Ateş Kadıoğlu2, Tolga Akman3, Ayşe Gül Bayrak3, Erkan Efe1. 1. Department of Urology, Kahramanmaraş Sütçü İmam University Faculty of Medicine, Kahramanmaraş, Turkey. 2. Department of Urology, İstanbul University Faculty of Medicine, İstanbul, Turkey. 3. Department of Internal Diseases, İstanbul University Faculty of Medicine, İstanbul, Turkey.
Abstract
BACKGROUND: Carriers of structural chromosomal rearrangements such as Robertsonian or reciprocal translocations have an increased risk of spontaneous abortion and producing offspring with genetic abnormalities. CASE REPORT: We report a man with balanced chromosomal translocations located at 6p22, and 7q22. His wife has a history of four spontaneous abortions. CONCLUSION: Couples with a history of abortions should be investigated cytogenetically, after other causes of miscarriages are excluded. The possibility of spontaneous abortions can be reduced with preimplantation genetic diagnosis (PGD) before embryo transfer.
BACKGROUND: Carriers of structural chromosomal rearrangements such as Robertsonian or reciprocal translocations have an increased risk of spontaneous abortion and producing offspring with genetic abnormalities. CASE REPORT: We report a man with balanced chromosomal translocations located at 6p22, and 7q22. His wife has a history of four spontaneous abortions. CONCLUSION: Couples with a history of abortions should be investigated cytogenetically, after other causes of miscarriages are excluded. The possibility of spontaneous abortions can be reduced with preimplantation genetic diagnosis (PGD) before embryo transfer.
Authors: Chun Kyu Lim; Jin Hyun Jun; Dong Mi Min; Hyoung-Song Lee; Jin Young Kim; Mi Kyoung Koong; Inn Soo Kang Journal: Prenat Diagn Date: 2004-07 Impact factor: 3.050
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