Ultrasound measurement of the corpus callosum and neural development.

Sir, the recent report on “ultrasound measurement of the corpus callo-sum and neural development” is very interesting[1]. Liu et al. reported that “corpus callosum growth in premature infants is associated with neurobehavioral development during the early extrauterine stage[1].” In fact, the use of 3D ultrasound seems to be useful to determine corpus callosum abnormality[2]. However, the genetic counseling based on its result remains controversial[2]. Santo et al. found that normal outcome could be observed in about 65–75% of cases with detected abnormali-ties of corpus callosum[3]. The diagnostic sensitivity of the ultrasound is also the topic to be considered[4]. Inaccuracy of ultrasound can be commonly seen and this leads to the requirement of additional MRI investigation[5].