Literature DB >> 25206302

Pregnant inflammatory bowel disease patients may require counselling regarding live vaccines in newborns.

Adith Sekaran1, Marie L Borum1.   

Abstract

Inflammatory bowel disease patients are prone to immunosuppression due to effects of their medications. Physicians are recommended to assess vaccination status and overall health in all patients, prior to initiation of immunosuppressive therapy. Immunosuppressant medications in women with inflammatory bowel disease are often continued during pregnancy, which can result in newborns having an increased risk of immunosuppression at birth. While medication-induced immunosuppression in infants is transient, parents should be counselled about delaying live vaccine administration in newborns until they are immune competent. A retrospective study was done over six months at an urban multispecialty medical center to assess whether physicians are counselling pregnant immunosuppressed inflammatory bowel disease patients regarding live vaccinations in their newborns. The study revealed that only 57% of patients had documented counselling in their charts. Further studies are necessary to determine physician counselling practices of pregnant women about live vaccines. It is critical that physicians and patients are aware of the risks of immunosuppression in pregnancy and the potential impact of live vaccines upon the newborn.

Entities:  

Keywords:  Inflammatory bowel disease; Pregnancy; Vaccines

Mesh:

Substances:

Year:  2014        PMID: 25206302      PMCID: PMC4155388          DOI: 10.3748/wjg.v20.i33.11927

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN: 1007-9327            Impact factor:   5.742


  5 in total

1.  European evidenced-based consensus on reproduction in inflammatory bowel disease.

Authors:  C Janneke van der Woude; Sanja Kolacek; Iris Dotan; Tom Oresland; Séverine Vermeire; Pia Munkholm; Uma Mahadevan; Lucy Mackillop; Axel Dignass
Journal:  J Crohns Colitis       Date:  2010-09-15       Impact factor: 9.071

2.  Fatal case of disseminated BCG infection after vaccination of an infant with in utero exposure to infliximab.

Authors:  Misha M Heller; Jashin J Wu; Jenny E Murase
Journal:  J Am Acad Dermatol       Date:  2011-10       Impact factor: 11.527

Review 3.  Vaccines and recommendations for their use in inflammatory bowel disease.

Authors:  María Dolores Sánchez-Tembleque; Carmen Corella; Jose L Pérez-Calle
Journal:  World J Gastroenterol       Date:  2013-03-07       Impact factor: 5.742

4.  Case Report: Fatal case of disseminated BCG infection in an infant born to a mother taking infliximab for Crohn's disease.

Authors:  Kuldeep Cheent; Jonathan Nolan; Sohail Shariq; Liina Kiho; Arabinda Pal; Jayantha Arnold
Journal:  J Crohns Colitis       Date:  2010-06-09       Impact factor: 9.071

Review 5.  Placental transport of immunoglobulins: a clinical review for gastroenterologists who prescribe therapeutic monoclonal antibodies to women during conception and pregnancy.

Authors:  Sunanda V Kane; Letitia A Acquah
Journal:  Am J Gastroenterol       Date:  2009-01       Impact factor: 10.864

  5 in total

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