| Literature DB >> 21122568 |
Kuldeep Cheent1, Jonathan Nolan, Sohail Shariq, Liina Kiho, Arabinda Pal, Jayantha Arnold.
Abstract
We present the case of a 28 year old lady with refractory Crohn's Disease treated with infliximab throughout her pregnancy. Her baby was born healthy and received a Bacillus Calmette-Guérin (BCG) vaccine aged 3 months. Soon after this the infant became unwell and died aged 4.5 months. At post-mortem the cause of death was attributed to an unusual complication of the BCG vaccine, known as disseminated BCG. BCG vaccination is contraindicated in individuals who are receiving immunosuppressive drugs. We recommend physicians should exercise caution before such vaccines are used in infants born to mothers taking anti-TNF therapies or other potentially immunosuppressive IgG1 antibodies.Entities:
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Year: 2010 PMID： 21122568 DOI： 10.1016/j.crohns.2010.05.001
Source DB: PubMed Journal: J Crohns Colitis ISSN： 1873-9946 Impact factor: 9.071