Literature DB >> 25203323

The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression.

Yang Wang1, Dan Chen2, Haili Qian3, Yihsuan S Tsai4, Shujuan Shao5, Quentin Liu6, Daniel Dominguez4, Zefeng Wang7.   

Abstract

Splicing dysregulation is one of the molecular hallmarks of cancer. However, the underlying molecular mechanisms remain poorly defined. Here we report that the splicing factor RBM4 suppresses proliferation and migration of various cancer cells by specifically controlling cancer-related splicing. Particularly, RBM4 regulates Bcl-x splicing to induce apoptosis, and coexpression of Bcl-xL partially reverses the RBM4-mediated tumor suppression. Moreover, RBM4 antagonizes an oncogenic splicing factor, SRSF1, to inhibit mTOR activation. Strikingly, RBM4 expression is decreased dramatically in cancer patients, and the RBM4 level correlates positively with improved survival. In addition to providing mechanistic insights of cancer-related splicing dysregulation, this study establishes RBM4 as a tumor suppressor with therapeutic potential and clinical values as a prognostic factor.
Copyright © 2014 Elsevier Inc. All rights reserved.

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Year:  2014        PMID： 25203323      PMCID： PMC4159621          DOI： 10.1016/j.ccr.2014.07.010

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  49 in total

Review 1.  Cancer-Associated Perturbations in Alternative Pre-messenger RNA Splicing.

Authors:  Lulzim Shkreta; Brendan Bell; Timothée Revil; Julian P Venables; Panagiotis Prinos; Sherif Abou Elela; Benoit Chabot
Journal:  Cancer Treat Res       Date:  2013

2.  A novel splicing regulator shares a nuclear import pathway with SR proteins.

Authors:  Ming-Chih Lai; Hao-Wei Kuo; Wen-Cheng Chang; Woan-Yuh Tarn
Journal:  EMBO J       Date:  2003-03-17       Impact factor: 11.598

3.  Bcl-XL small interfering RNA suppresses the proliferation of 5-fluorouracil-resistant human colon cancer cells.

Authors:  Hongbo Zhu; Wei Guo; Lidong Zhang; John J Davis; Fuminori Teraishi; Shuhong Wu; Xiaobo Cao; Jonathan Daniel; W Roy Smythe; Bingliang Fang
Journal:  Mol Cancer Ther       Date:  2005-03       Impact factor: 6.261

4.  S6K1 alternative splicing modulates its oncogenic activity and regulates mTORC1.

Authors:  Vered Ben-Hur; Polina Denichenko; Zahava Siegfried; Avi Maimon; Adrian Krainer; Ben Davidson; Rotem Karni
Journal:  Cell Rep       Date:  2012-12-27       Impact factor: 9.423

Review 5.  Regulation of apoptosis by alternative pre-mRNA splicing.

Authors:  Christian Schwerk; Klaus Schulze-Osthoff
Journal:  Mol Cell       Date:  2005-07-01       Impact factor: 17.970

6.  The gene encoding the splicing factor SF2/ASF is a proto-oncogene.

Authors:  Rotem Karni; Elisa de Stanchina; Scott W Lowe; Rahul Sinha; David Mu; Adrian R Krainer
Journal:  Nat Struct Mol Biol       Date:  2007-02-18       Impact factor: 15.369

7.  Cell stress modulates the function of splicing regulatory protein RBM4 in translation control.

Authors:  Jung-Chun Lin; Min Hsu; Woan-Yuh Tarn
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-06       Impact factor: 11.205

Review 8.  CD44 integrates signaling in normal stem cell, cancer stem cell and (pre)metastatic niches.

Authors:  Karin Williams; Karan Motiani; Premkumar Vummidi Giridhar; Susan Kasper
Journal:  Exp Biol Med (Maywood)       Date:  2013-03

9.  Stromal gene expression predicts clinical outcome in breast cancer.

Authors:  Greg Finak; Nicholas Bertos; Francois Pepin; Svetlana Sadekova; Margarita Souleimanova; Hong Zhao; Haiying Chen; Gulbeyaz Omeroglu; Sarkis Meterissian; Atilla Omeroglu; Michael Hallett; Morag Park
Journal:  Nat Med       Date:  2008-04-27       Impact factor: 53.440

10.  Identification of alternative splicing markers for breast cancer.

Authors:  Julian P Venables; Roscoe Klinck; Anne Bramard; Lyna Inkel; Geneviève Dufresne-Martin; ChuShin Koh; Julien Gervais-Bird; Elvy Lapointe; Ulrike Froehlich; Mathieu Durand; Daniel Gendron; Jean-Philippe Brosseau; Philippe Thibault; Jean-Francois Lucier; Karine Tremblay; Panagiotis Prinos; Raymund J Wellinger; Benoit Chabot; Claudine Rancourt; Sherif Abou Elela
Journal:  Cancer Res       Date:  2008-11-15       Impact factor: 12.701
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  89 in total

1.  Quantitative proteomic analyses of mammary organoids reveals distinct signatures after exposure to environmental chemicals.

Authors:  Katherine E Williams; George A Lemieux; Maria E Hassis; Adam B Olshen; Susan J Fisher; Zena Werb
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-22       Impact factor: 11.205

Review 2.  Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes.

Authors:  A Sveen; S Kilpinen; A Ruusulehto; R A Lothe; R I Skotheim
Journal:  Oncogene       Date:  2015-08-24       Impact factor: 9.867

3.  RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M.

Authors:  Chun-Hao Su; Kuan-Yang Hung; Shih-Chieh Hung; Woan-Yuh Tarn
Journal:  Mol Cell Biol       Date:  2017-01-19       Impact factor: 4.272

4.  A transcriptomic insight into the impacts of mast cells in lung, breast, and colon cancers.

Authors:  Eun-A Ko; Kenton M Sanders; Tong Zhou
Journal:  Oncoimmunology       Date:  2017-08-08       Impact factor: 8.110

5.  Expanding RNA binding specificity and affinity of engineered PUF domains.

Authors:  Yang-Yang Zhao; Miao-Wei Mao; Wen-Jing Zhang; Jue Wang; Hai-Tao Li; Yi Yang; Zefeng Wang; Jia-Wei Wu
Journal:  Nucleic Acids Res       Date:  2018-05-18       Impact factor: 16.971

Review 6.  Role of Alternative Splicing in Prostate Cancer Aggressiveness and Drug Resistance in African Americans.

Authors:  Jacqueline Olender; Norman H Lee
Journal:  Adv Exp Med Biol       Date:  2019       Impact factor: 2.622

7.  RBM4 modulates the proliferation and expression of inflammatory factors via the alternative splicing of regulatory factors in HeLa cells.

Authors:  Wei-Yang Wang; Weili Quan; Fan Yang; Ya-Xun Wei; Jia-Jun Chen; Han Yu; Jie Xie; Yi Zhang; Zhan-Fei Li
Journal:  Mol Genet Genomics       Date:  2019-09-05       Impact factor: 3.291

Review 8.  Hyperinsulinaemia in cancer.

Authors:  Emily J Gallagher; Derek LeRoith
Journal:  Nat Rev Cancer       Date:  2020-09-09       Impact factor: 60.716

9.  Interferon regulatory factor 1 and a variant of heterogeneous nuclear ribonucleoprotein L coordinately silence the gene for adhesion protein CEACAM1.

Authors:  Kenneth J Dery; Craig Silver; Lu Yang; John E Shively
Journal:  J Biol Chem       Date:  2018-05-02       Impact factor: 5.157

Review 10.  Biology of the mRNA Splicing Machinery and Its Dysregulation in Cancer Providing Therapeutic Opportunities.

Authors:  Maxime Blijlevens; Jing Li; Victor W van Beusechem
Journal:  Int J Mol Sci       Date:  2021-05-12       Impact factor: 5.923
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