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Literature DB >> 25202874

Centromere licensing: Mis18 is required to Polo-ver.

Meghan C Barnhart-Dailey¹, Daniel R Foltz².

Abstract

The Mis18 complex is a critical player in determining when and where centromeres are built. A new study identifies Polo-like kinase (Plk1) as a positive regulator required for the localization of Mis18 to centromeres. This is a critical step that is essential for proper centromere function and maintaining the integrity of the genome.

Entities: Gene Species

Mesh：

Substances：

Year: 2014 PMID： 25202874 PMCID： PMC5881566 DOI： 10.1016/j.cub.2014.07.026

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

14 in total

1. Cdk activity couples epigenetic centromere inheritance to cell cycle progression.

Authors: Mariana C C Silva; Dani L Bodor; Madison E Stellfox; Nuno M C Martins; Helfrid Hochegger; Daniel R Foltz; Lars E T Jansen
Journal: Dev Cell Date: 2011-12-08 Impact factor: 12.270

Review 2. Putting CENP-A in its place.

Authors: Madison E Stellfox; Aaron O Bailey; Daniel R Foltz
Journal: Cell Mol Life Sci Date: 2012-06-23 Impact factor: 9.261

Centromere licensing: Mis18 is required to Polo-ver.

1. Cdk activity couples epigenetic centromere inheritance to cell cycle progression.

Review 2. Putting CENP-A in its place.

Review 3. Pericentric heterochromatin: dynamic organization during early development in mammals.

Review 4. Epigenetic inheritance during the cell cycle.

5. Polo-like kinase 1 licenses CENP-A deposition at centromeres.

6. Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.

7. CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin.

8. Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin.

9. Propagation of centromeric chromatin requires exit from mitosis.

10. Assembly in G1 phase and long-term stability are unique intrinsic features of CENP-A nucleosomes.

1. Licensing of Centromeric Chromatin Assembly through the Mis18α-Mis18β Heterotetramer.

2. The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores.