PURPOSE: Sedentary behavior is linked to numerous poor health outcomes. This study aims to determine the effects of 7 d of increased sitting on markers of cardiometabolic risk among free-living individuals. METHODS: Ten recreationally active participants (>150 min of moderate-intensity physical activity per week; mean ± SD age, 25.2 ± 5.7 yr; mean ± SD body mass index, 24.9 ± 4.3 kg·m(-2)) completed a 7-d baseline period and a 7-d sedentary condition in their free-living environment. At baseline, participants maintained normal activity. After baseline, participants completed a 7-d sedentary condition. Participants were instructed to sit as much as possible, to limit standing and walking, and to refrain from structured exercise and leisure time physical activity. ActivPAL monitor was used to assess sedentary behavior and physical activity. Fasting lipids, glucose, and insulin were measured, and oral glucose tolerance test was performed after baseline and sedentary condition. RESULTS: In comparison to baseline, total sedentary time (mean Δ, 14.9%; 95% CI, 10.2-19.6) and time in prolonged/uninterrupted sedentary bouts significantly increased, whereas the rate of breaks from sedentary time was significantly reduced (mean Δ, 21.4%; 95% CI, 6.9-35.9). For oral glucose tolerance test, 2-h plasma insulin (mean Δ, 38.8 μU·mL(-1); 95% CI, 10.9-66.8) and area under the insulin curve (mean Δ, 3074.1 μU·mL(-1) per 120 min; 95% CI, 526.0-5622.3) were significantly elevated after the sedentary condition. Lipid concentrations did not change. Change in 2-h insulin was negatively associated with change in light-intensity activity (r = -0.62) and positively associated with change in time in sitting bouts longer than 30 min (r = 0.82) and 60 min (r = 0.83). CONCLUSION: Increased free-living sitting negatively impacts markers of cardiometabolic health, and specific features of sedentary behavior (e.g., time in prolonged sitting bouts) may be particularly important.
PURPOSE: Sedentary behavior is linked to numerous poor health outcomes. This study aims to determine the effects of 7 d of increased sitting on markers of cardiometabolic risk among free-living individuals. METHODS: Ten recreationally active participants (>150 min of moderate-intensity physical activity per week; mean ± SD age, 25.2 ± 5.7 yr; mean ± SD body mass index, 24.9 ± 4.3 kg·m(-2)) completed a 7-d baseline period and a 7-d sedentary condition in their free-living environment. At baseline, participants maintained normal activity. After baseline, participants completed a 7-d sedentary condition. Participants were instructed to sit as much as possible, to limit standing and walking, and to refrain from structured exercise and leisure time physical activity. ActivPAL monitor was used to assess sedentary behavior and physical activity. Fasting lipids, glucose, and insulin were measured, and oral glucose tolerance test was performed after baseline and sedentary condition. RESULTS: In comparison to baseline, total sedentary time (mean Δ, 14.9%; 95% CI, 10.2-19.6) and time in prolonged/uninterrupted sedentary bouts significantly increased, whereas the rate of breaks from sedentary time was significantly reduced (mean Δ, 21.4%; 95% CI, 6.9-35.9). For oral glucose tolerance test, 2-h plasma insulin (mean Δ, 38.8 μU·mL(-1); 95% CI, 10.9-66.8) and area under the insulin curve (mean Δ, 3074.1 μU·mL(-1) per 120 min; 95% CI, 526.0-5622.3) were significantly elevated after the sedentary condition. Lipid concentrations did not change. Change in 2-h insulin was negatively associated with change in light-intensity activity (r = -0.62) and positively associated with change in time in sitting bouts longer than 30 min (r = 0.82) and 60 min (r = 0.83). CONCLUSION: Increased free-living sitting negatively impacts markers of cardiometabolic health, and specific features of sedentary behavior (e.g., time in prolonged sitting bouts) may be particularly important.
Authors: Sarah Kozey-Keadle; Amanda Libertine; Kate Lyden; John Staudenmayer; Patty S Freedson Journal: Med Sci Sports Exerc Date: 2011-08 Impact factor: 5.411
Authors: Catherine R Mikus; Douglas J Oberlin; Jessica L Libla; Angelina M Taylor; Frank W Booth; John P Thyfault Journal: Med Sci Sports Exerc Date: 2012-02 Impact factor: 5.411
Authors: Brooke R Stephens; Kirsten Granados; Theodore W Zderic; Marc T Hamilton; Barry Braun Journal: Metabolism Date: 2010-11-10 Impact factor: 8.694
Authors: Bernard M F M Duvivier; Nicolaas C Schaper; Michelle A Bremers; Glenn van Crombrugge; Paul P C A Menheere; Marleen Kars; Hans H C M Savelberg Journal: PLoS One Date: 2013-02-13 Impact factor: 3.240
Authors: David W Dunstan; Bronwyn A Kingwell; Robyn Larsen; Genevieve N Healy; Ester Cerin; Marc T Hamilton; Jonathan E Shaw; David A Bertovic; Paul Z Zimmet; Jo Salmon; Neville Owen Journal: Diabetes Care Date: 2012-02-28 Impact factor: 19.112
Authors: Lynette L Craft; Theodore W Zderic; Susan M Gapstur; Erik H Vaniterson; Danielle M Thomas; Juned Siddique; Marc T Hamilton Journal: Int J Behav Nutr Phys Act Date: 2012-10-04 Impact factor: 6.457
Authors: Sheri J Hartman; Catherine R Marinac; John Bellettiere; Suneeta Godbole; Loki Natarajan; Ruth E Patterson; Jacqueline Kerr Journal: Support Care Cancer Date: 2017-03-22 Impact factor: 3.603
Authors: Sarah Kozey Keadle; Joshua N Sampson; Haocheng Li; Kate Lyden; Charles E Matthews; Raymond J Carroll Journal: Med Sci Sports Exerc Date: 2017-01 Impact factor: 5.411
Authors: Jennifer A Schrack; Rachel Cooper; Annemarie Koster; Eric J Shiroma; Joanne M Murabito; W Jack Rejeski; Luigi Ferrucci; Tamara B Harris Journal: J Gerontol A Biol Sci Med Sci Date: 2016-03-08 Impact factor: 6.053