Qiuji Shao1, Liangfu Zhu1, Tianxiao Li2, Li Li1, Dujuan Li3, Jiaqiang Zhang4, Wei Ren5, Liheng Wu1. 1. Department of Interventional Therapy, Henan Provincial People's Hospital Affiliated to Zhengzhou University, Zhengzhou, China. 2. Department of Interventional Therapy, Henan Provincial People's Hospital Affiliated to Zhengzhou University, Zhengzhou, China. Electronic address: dr.litianxiao@vip.163.com. 3. Department of Pathology, Henan Provincial People's Hospital Affiliated to Zhengzhou University, Zhengzhou, China. 4. Department of anesthesiology, Henan Provincial People's Hospital Affiliated to Zhengzhou University, Zhengzhou, China. 5. Catheter room, Henan Provincial People's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Abstract
BACKGROUND: Mechanical thrombectomy is a promising new modality of interventional stroke treatment. Preparation of thrombus is a very important step for the evaluation of the mechanical thrombectomy devices. The objective of this study was to explore a new method of thrombus preparation with fluid model (FM) for assessment of thrombectomy devices used in the recanalization of acute ischemic stroke. METHODS: Elongation test and catheter injection test were used to evaluate the mechanical properties of thrombi prepared by FM and static model (SM). Histological structures of two artificial clots and specimens of stroke patients were compared. Radiopacity of thrombus made by FM was evaluated in a swine embolization model. RESULTS: The maximum tensile length of thrombi prepared by FM and SM were significantly higher (4.28 ± 0.23 cm vs 3.16 ± 0.13 cm, P < 0.01) and showed less breakage on catheter injection test (13% vs 60%, P < 0.05). Histological features of thrombi prepared by FM showed mixed thrombus structure, similar to thromboemboli retrieved from acute stroke patients, while clots generated by SM were replete with erythrocytes. A total of twelve vessels in two swine were successfully occluded (TIMI 0 or 1), with sufficient radiopacity of each injected thrombus. CONCLUSION: The thrombus prepared by FM had good mechanical stability, sufficient radiopacity, and similar histological structure of thromboemboli retrieved from stroke patients, which make it possible to be used in the evaluation of thrombectomy devices.
BACKGROUND: Mechanical thrombectomy is a promising new modality of interventional stroke treatment. Preparation of thrombus is a very important step for the evaluation of the mechanical thrombectomy devices. The objective of this study was to explore a new method of thrombus preparation with fluid model (FM) for assessment of thrombectomy devices used in the recanalization of acute ischemic stroke. METHODS: Elongation test and catheter injection test were used to evaluate the mechanical properties of thrombi prepared by FM and static model (SM). Histological structures of two artificial clots and specimens of strokepatients were compared. Radiopacity of thrombus made by FM was evaluated in a swine embolization model. RESULTS: The maximum tensile length of thrombi prepared by FM and SM were significantly higher (4.28 ± 0.23 cm vs 3.16 ± 0.13 cm, P < 0.01) and showed less breakage on catheter injection test (13% vs 60%, P < 0.05). Histological features of thrombi prepared by FM showed mixed thrombus structure, similar to thromboemboli retrieved from acute strokepatients, while clots generated by SM were replete with erythrocytes. A total of twelve vessels in two swine were successfully occluded (TIMI 0 or 1), with sufficient radiopacity of each injected thrombus. CONCLUSION: The thrombus prepared by FM had good mechanical stability, sufficient radiopacity, and similar histological structure of thromboemboli retrieved from strokepatients, which make it possible to be used in the evaluation of thrombectomy devices.
Authors: Jeffrey K Yang; Andre M Cote; Caroline D Jordan; Sravani Kondapavulur; Aaron D Losey; David McCoy; Andrew Chu; Jay F Yu; Teri Moore; Carol Stillson; Fabio Settecase; Matthew D Alexander; Andrew Nicholson; Daniel L Cooke; Maythem Saeed; Dave Barry; Alastair J Martin; Mark W Wilson; Steven W Hetts Journal: Biomed Microdevices Date: 2017-09-25 Impact factor: 2.838
Authors: Yang Liu; Mehdi Abbasi; Jorge L Arturo Larco; Ramanathan Kadirvel; David F Kallmes; Waleed Brinjikji; Luis Savastano Journal: J Neurointerv Surg Date: 2021-03-15 Impact factor: 8.572