Literature DB >> 25200284

Decade in review--dyslipidaemia: Resurgence of targets and compounds to treat dyslipidaemia.

John J P Kastelein1.   

Abstract

Over the past decade, we have witnessed the unparalleled success of statins to treat dyslipidaemia. Target identification by Mendelian randomization, human monoclonal antibodies, gene therapy, RNA-based targets, and atherogenic lipoproteins other than LDL cholesterol have fuelled intense development efforts that might bear fruit in the very near future.

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Year:  2014        PMID： 25200284     DOI： 10.1038/nrcardio.2014.132

Source DB:  PubMed          Journal:  Nat Rev Cardiol        ISSN： 1759-5002            Impact factor:   32.419


  10 in total

1.  Intramuscular administration of AAV1-lipoprotein lipase S447X lowers triglycerides in lipoprotein lipase-deficient patients.

Authors:  Erik S Stroes; Melchior C Nierman; Janneke J Meulenberg; Remco Franssen; Jaap Twisk; C Pieter Henny; Mario M Maas; Aeilko H Zwinderman; Colin Ross; Eleonora Aronica; Katherine A High; Marcel M Levi; Michael R Hayden; John J Kastelein; Jan Albert Kuivenhoven
Journal:  Arterioscler Thromb Vasc Biol       Date:  2008-09-18       Impact factor: 8.311

2.  Effect of a monoclonal antibody to PCSK9 on LDL cholesterol.

Authors:  Evan A Stein; Scott Mellis; George D Yancopoulos; Neil Stahl; Douglas Logan; William B Smith; Eleanor Lisbon; Maria Gutierrez; Cheryle Webb; Richard Wu; Yunling Du; Therese Kranz; Evelyn Gasparino; Gary D Swergold
Journal:  N Engl J Med       Date:  2012-03-22       Impact factor: 91.245

3.  Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B.

Authors:  John J P Kastelein; Mark K Wedel; Brenda F Baker; John Su; JoAnn D Bradley; Rosie Z Yu; Emil Chuang; Mark J Graham; Rosanne M Crooke
Journal:  Circulation       Date:  2006-10-09       Impact factor: 29.690

4.  Intensive lipid lowering with atorvastatin in patients with stable coronary disease.

Authors:  John C LaRosa; Scott M Grundy; David D Waters; Charles Shear; Philip Barter; Jean-Charles Fruchart; Antonio M Gotto; Heiner Greten; John J P Kastelein; James Shepherd; Nanette K Wenger
Journal:  N Engl J Med       Date:  2005-03-08       Impact factor: 91.245

5.  Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein.

Authors:  Paul M Ridker; Eleanor Danielson; Francisco A H Fonseca; Jacques Genest; Antonio M Gotto; John J P Kastelein; Wolfgang Koenig; Peter Libby; Alberto J Lorenzatti; Jean G MacFadyen; Børge G Nordestgaard; James Shepherd; James T Willerson; Robert J Glynn
Journal:  N Engl J Med       Date:  2008-11-09       Impact factor: 91.245

6.  Intensive versus moderate lipid lowering with statins after acute coronary syndromes.

Authors:  Christopher P Cannon; Eugene Braunwald; Carolyn H McCabe; Daniel J Rader; Jean L Rouleau; Rene Belder; Steven V Joyal; Karen A Hill; Marc A Pfeffer; Allan M Skene
Journal:  N Engl J Med       Date:  2004-03-08       Impact factor: 91.245

7.  Genetically elevated lipoprotein(a) and increased risk of myocardial infarction.

Authors:  Pia R Kamstrup; Anne Tybjaerg-Hansen; Rolf Steffensen; Børge G Nordestgaard
Journal:  JAMA       Date:  2009-06-10       Impact factor: 56.272

8.  Loss-of-function mutations in APOC3, triglycerides, and coronary disease.

Authors:  Jacy Crosby; Gina M Peloso; Paul L Auer; David R Crosslin; Nathan O Stitziel; Leslie A Lange; Yingchang Lu; Zheng-zheng Tang; He Zhang; George Hindy; Nicholas Masca; Kathleen Stirrups; Stavroula Kanoni; Ron Do; Goo Jun; Youna Hu; Hyun Min Kang; Chenyi Xue; Anuj Goel; Martin Farrall; Stefano Duga; Pier Angelica Merlini; Rosanna Asselta; Domenico Girelli; Oliviero Olivieri; Nicola Martinelli; Wu Yin; Dermot Reilly; Elizabeth Speliotes; Caroline S Fox; Kristian Hveem; Oddgeir L Holmen; Majid Nikpay; Deborah N Farlow; Themistocles L Assimes; Nora Franceschini; Jennifer Robinson; Kari E North; Lisa W Martin; Mark DePristo; Namrata Gupta; Stefan A Escher; Jan-Håkan Jansson; Natalie Van Zuydam; Colin N A Palmer; Nicholas Wareham; Werner Koch; Thomas Meitinger; Annette Peters; Wolfgang Lieb; Raimund Erbel; Inke R Konig; Jochen Kruppa; Franziska Degenhardt; Omri Gottesman; Erwin P Bottinger; Christopher J O'Donnell; Bruce M Psaty; Christie M Ballantyne; Goncalo Abecasis; Jose M Ordovas; Olle Melander; Hugh Watkins; Marju Orho-Melander; Diego Ardissino; Ruth J F Loos; Ruth McPherson; Cristen J Willer; Jeanette Erdmann; Alistair S Hall; Nilesh J Samani; Panos Deloukas; Heribert Schunkert; James G Wilson; Charles Kooperberg; Stephen S Rich; Russell P Tracy; Dan-Yu Lin; David Altshuler; Stacey Gabriel; Deborah A Nickerson; Gail P Jarvik; L Adrienne Cupples; Alex P Reiner; Eric Boerwinkle; Sekar Kathiresan
Journal:  N Engl J Med       Date:  2014-06-18       Impact factor: 91.245

9.  Loss-of-function mutations in APOC3 and risk of ischemic vascular disease.

Authors:  Anders Berg Jørgensen; Ruth Frikke-Schmidt; Børge G Nordestgaard; Anne Tybjærg-Hansen
Journal:  N Engl J Med       Date:  2014-06-18       Impact factor: 91.245

10.  Common variants associated with plasma triglycerides and risk for coronary artery disease.

Authors:  Ron Do; Cristen J Willer; Ellen M Schmidt; Sebanti Sengupta; Chi Gao; Gina M Peloso; Stefan Gustafsson; Stavroula Kanoni; Andrea Ganna; Jin Chen; Martin L Buchkovich; Samia Mora; Jacques S Beckmann; Jennifer L Bragg-Gresham; Hsing-Yi Chang; Ayşe Demirkan; Heleen M Den Hertog; Louise A Donnelly; Georg B Ehret; Tõnu Esko; Mary F Feitosa; Teresa Ferreira; Krista Fischer; Pierre Fontanillas; Ross M Fraser; Daniel F Freitag; Deepti Gurdasani; Kauko Heikkilä; Elina Hyppönen; Aaron Isaacs; Anne U Jackson; Asa Johansson; Toby Johnson; Marika Kaakinen; Johannes Kettunen; Marcus E Kleber; Xiaohui Li; Jian'an Luan; Leo-Pekka Lyytikäinen; Patrik K E Magnusson; Massimo Mangino; Evelin Mihailov; May E Montasser; Martina Müller-Nurasyid; Ilja M Nolte; Jeffrey R O'Connell; Cameron D Palmer; Markus Perola; Ann-Kristin Petersen; Serena Sanna; Richa Saxena; Susan K Service; Sonia Shah; Dmitry Shungin; Carlo Sidore; Ci Song; Rona J Strawbridge; Ida Surakka; Toshiko Tanaka; Tanya M Teslovich; Gudmar Thorleifsson; Evita G Van den Herik; Benjamin F Voight; Kelly A Volcik; Lindsay L Waite; Andrew Wong; Ying Wu; Weihua Zhang; Devin Absher; Gershim Asiki; Inês Barroso; Latonya F Been; Jennifer L Bolton; Lori L Bonnycastle; Paolo Brambilla; Mary S Burnett; Giancarlo Cesana; Maria Dimitriou; Alex S F Doney; Angela Döring; Paul Elliott; Stephen E Epstein; Gudmundur Ingi Eyjolfsson; Bruna Gigante; Mark O Goodarzi; Harald Grallert; Martha L Gravito; Christopher J Groves; Göran Hallmans; Anna-Liisa Hartikainen; Caroline Hayward; Dena Hernandez; Andrew A Hicks; Hilma Holm; Yi-Jen Hung; Thomas Illig; Michelle R Jones; Pontiano Kaleebu; John J P Kastelein; Kay-Tee Khaw; Eric Kim; Norman Klopp; Pirjo Komulainen; Meena Kumari; Claudia Langenberg; Terho Lehtimäki; Shih-Yi Lin; Jaana Lindström; Ruth J F Loos; François Mach; Wendy L McArdle; Christa Meisinger; Braxton D Mitchell; Gabrielle Müller; Ramaiah Nagaraja; Narisu Narisu; Tuomo V M Nieminen; Rebecca N Nsubuga; Isleifur Olafsson; Ken K Ong; Aarno Palotie; Theodore Papamarkou; Cristina Pomilla; Anneli Pouta; Daniel J Rader; Muredach P Reilly; Paul M Ridker; Fernando Rivadeneira; Igor Rudan; Aimo Ruokonen; Nilesh Samani; Hubert Scharnagl; Janet Seeley; Kaisa Silander; Alena Stančáková; Kathleen Stirrups; Amy J Swift; Laurence Tiret; Andre G Uitterlinden; L Joost van Pelt; Sailaja Vedantam; Nicholas Wainwright; Cisca Wijmenga; Sarah H Wild; Gonneke Willemsen; Tom Wilsgaard; James F Wilson; Elizabeth H Young; Jing Hua Zhao; Linda S Adair; Dominique Arveiler; Themistocles L Assimes; Stefania Bandinelli; Franklyn Bennett; Murielle Bochud; Bernhard O Boehm; Dorret I Boomsma; Ingrid B Borecki; Stefan R Bornstein; Pascal Bovet; Michel Burnier; Harry Campbell; Aravinda Chakravarti; John C Chambers; Yii-Der Ida Chen; Francis S Collins; Richard S Cooper; John Danesh; George Dedoussis; Ulf de Faire; Alan B Feranil; Jean Ferrières; Luigi Ferrucci; Nelson B Freimer; Christian Gieger; Leif C Groop; Vilmundur Gudnason; Ulf Gyllensten; Anders Hamsten; Tamara B Harris; Aroon Hingorani; Joel N Hirschhorn; Albert Hofman; G Kees Hovingh; Chao Agnes Hsiung; Steve E Humphries; Steven C Hunt; Kristian Hveem; Carlos Iribarren; Marjo-Riitta Järvelin; Antti Jula; Mika Kähönen; Jaakko Kaprio; Antero Kesäniemi; Mika Kivimaki; Jaspal S Kooner; Peter J Koudstaal; Ronald M Krauss; Diana Kuh; Johanna Kuusisto; Kirsten O Kyvik; Markku Laakso; Timo A Lakka; Lars Lind; Cecilia M Lindgren; Nicholas G Martin; Winfried März; Mark I McCarthy; Colin A McKenzie; Pierre Meneton; Andres Metspalu; Leena Moilanen; Andrew D Morris; Patricia B Munroe; Inger Njølstad; Nancy L Pedersen; Chris Power; Peter P Pramstaller; Jackie F Price; Bruce M Psaty; Thomas Quertermous; Rainer Rauramaa; Danish Saleheen; Veikko Salomaa; Dharambir K Sanghera; Jouko Saramies; Peter E H Schwarz; Wayne H-H Sheu; Alan R Shuldiner; Agneta Siegbahn; Tim D Spector; Kari Stefansson; David P Strachan; Bamidele O Tayo; Elena Tremoli; Jaakko Tuomilehto; Matti Uusitupa; Cornelia M van Duijn; Peter Vollenweider; Lars Wallentin; Nicholas J Wareham; John B Whitfield; Bruce H R Wolffenbuttel; David Altshuler; Jose M Ordovas; Eric Boerwinkle; Colin N A Palmer; Unnur Thorsteinsdottir; Daniel I Chasman; Jerome I Rotter; Paul W Franks; Samuli Ripatti; L Adrienne Cupples; Manjinder S Sandhu; Stephen S Rich; Michael Boehnke; Panos Deloukas; Karen L Mohlke; Erik Ingelsson; Goncalo R Abecasis; Mark J Daly; Benjamin M Neale; Sekar Kathiresan
Journal:  Nat Genet       Date:  2013-10-06       Impact factor: 38.330
  10 in total
  4 in total

Review 1.  Targeting ApoC-III to Reduce Coronary Disease Risk.

Authors:  Sumeet A Khetarpal; Arman Qamar; John S Millar; Daniel J Rader
Journal:  Curr Atheroscler Rep       Date:  2016-09       Impact factor: 5.113

2.  Apolipoprotein CIII Overexpression-Induced Hypertriglyceridemia Increases Nonalcoholic Fatty Liver Disease in Association with Inflammation and Cell Death.

Authors:  Adriene A Paiva; Helena F Raposo; Amarylis C B A Wanschel; Tarlliza R Nardelli; Helena C F Oliveira
Journal:  Oxid Med Cell Longev       Date:  2017-01-10       Impact factor: 6.543

Review 3.  GWAS Reveal Targets in Vessel Wall Pathways to Treat Coronary Artery Disease.

Authors:  Adam W Turner; Doris Wong; Caitlin N Dreisbach; Clint L Miller
Journal:  Front Cardiovasc Med       Date:  2018-06-25

4.  ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia.

Authors:  John J P Kastelein; Henry N Ginsberg; Gisle Langslet; G Kees Hovingh; Richard Ceska; Robert Dufour; Dirk Blom; Fernando Civeira; Michel Krempf; Christelle Lorenzato; Jian Zhao; Robert Pordy; Marie T Baccara-Dinet; Daniel A Gipe; Mary Jane Geiger; Michel Farnier
Journal:  Eur Heart J       Date:  2015-09-01       Impact factor: 29.983
  4 in total

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