Literature DB >> 25199942

[Metamizole (dipyrone): mode of action, drug-drug interactions, and risk of agranulocytosis].

C Lampl1, R Likar.   

Abstract

Metamizole (dipyrone) is a nonsteroidal compound with strong analgesic as well as antipyretic and spasmolytic properties. Based on a small number of cases of agranulocytosis, metamizole was withdrawn from the market in some countries. Other countries restricted its use. This paper discusses the safety aspects of metamizole and compares it with other compounds used for similar indications.

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Year:  2014        PMID： 25199942     DOI： 10.1007/s00482-014-1490-7

Source DB:  PubMed          Journal:  Schmerz        ISSN： 0932-433X            Impact factor:   1.107


  37 in total

1.  Antinociception induced by PAG-microinjected dipyrone (metamizol) in rats: involvement of spinal endogenous opioids.

Authors:  N Hernández; H Vanegas
Journal:  Brain Res       Date:  2001-03-30       Impact factor: 3.252

Review 2.  Idiosyncratic drug reactions: a mechanistic evaluation of risk factors.

Authors:  B K Park; M Pirmohamed; N R Kitteringham
Journal:  Br J Clin Pharmacol       Date:  1992-11       Impact factor: 4.335

3.  Influence of mianserin on the antinociceptive effect of morphine, metamizol and indomethacin in mice.

Authors:  W Pakulska; E Czarnecka
Journal:  Pharmacol Res       Date:  2002-11       Impact factor: 7.658

4.  Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action.

Authors:  A Beirith; A R Santos; A L Rodrigues; T B Creczynski-Pasa; J B Calixto
Journal:  Eur J Pharmacol       Date:  1998-03-26       Impact factor: 4.432

5.  Regulation of cyclooxygenase activity by metamizol.

Authors:  C Campos; R de Gregorio; R García-Nieto; F Gago; P Ortiz; S Alemany
Journal:  Eur J Pharmacol       Date:  1999-08-13       Impact factor: 4.432

6.  [Metamizol versus propacetamol: comparative study of the hemodynamic and antipyretic effects in critically ill patients].

Authors:  P Cruz; I Garutti; S Díaz; L Fernández-Quero
Journal:  Rev Esp Anestesiol Reanim       Date:  2002-10

7.  Phenacetin, acetaminophen and dipyrone: analgesic and rewarding effects.

Authors:  F V Abbott; K G Hellemans
Journal:  Behav Brain Res       Date:  2000-07       Impact factor: 3.332

8.  Effects of parecoxib and dipyrone on platelet aggregation in patients undergoing meniscectomy: a double-blind, randomized, parallel-group study.

Authors:  Jochen Graff; Mohammed Arabmotlagh; Raymond Cheung; Gerd Geisslinger; Sebastian Harder
Journal:  Clin Ther       Date:  2007-03       Impact factor: 3.393

9.  A prospective study of the incidence of agranulocytosis and aplastic anemia associated with the oral use of metamizole sodium in Poland.

Authors:  Stanisław Maj; Piotr Centkowski
Journal:  Med Sci Monit       Date:  2004-08-20

10.  Naloxone partial reversal of the antinociception produced by dipyrone microinjected into the periaqueductal gray of rats. Possible involvement of medullary off- and on-cells.

Authors:  V Tortorici; E Vásquez; H Vanegas
Journal:  Brain Res       Date:  1996-06-24       Impact factor: 3.252
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  9 in total

1.  [Metamizole].

Authors:  K Güttler
Journal:  Schmerz       Date:  2015-04       Impact factor: 1.107

2.  [Side effects of pain therapy : Sufficient analgesia without unnecessary complications].

Authors:  F Greul; A Zimmer; W Meißner
Journal:  Urologe A       Date:  2017-04       Impact factor: 0.639

Review 3.  Impact of drugs on venous thromboembolism risk in surgical patients.

Authors:  Alenka Premuš Marušič Kovačič; Martin Caprnda; Aleš Mrhar; Peter Kubatka; Igor Locatelli; Barbora Zolakova; Ludovit Gaspar; Robert Prosecky; Peter Kruzliak; Robert Staffa; Luis Rodrigo; Jozef Radonak; Danijel Petrovič
Journal:  Eur J Clin Pharmacol       Date:  2019-02-05       Impact factor: 2.953

Review 4.  The Conservative Treatment of Traumatic Thoracolumbar Vertebral Fractures.

Authors:  Ulrich J Spiegl; Klaus Fischer; Jörg Schmidt; Jörg Schnoor; Stefan Delank; Christoph Josten; Tobias Schulte; Christoph-Eckhardt Heyde
Journal:  Dtsch Arztebl Int       Date:  2018-10-19       Impact factor: 5.594

Review 5.  [Considerations concerning the perioperative use of metamizole].

Authors:  R Sittl; P Bäumler; A-M Stumvoll; D Irnich; B Zwißler
Journal:  Anaesthesist       Date:  2019-08       Impact factor: 1.041

Review 6.  [Pain therapy for children and adolescents with hemophilia : Recommendations by an expert panel].

Authors:  W Stromer; B Messerer; R Crevenna; S H Hemberger; B Jauk; R Schwarz; W Streif; K Thom; B Wagner; K Zwiauer; R Likar
Journal:  Schmerz       Date:  2018-12       Impact factor: 1.107

7.  Metamizole versus placebo for panretinal photocoagulation pain control: a prospective double-masked randomized controlled study.

Authors:  Rafael Barbosa de Araújo; Leandro Cabral Zacharias; Breno Marques de Azevedo; Beatrice Schmidt Giusti; Rony Carlos Pretti; Walter Y Takahashi; Mário Luiz Ribeiro Monteiro
Journal:  Int J Retina Vitreous       Date:  2015-11-12

8.  Effects of metamizole, MAA, and paracetamol on proliferation, apoptosis, and necrosis in the pancreatic cancer cell lines PaTu 8988 t and Panc-1.

Authors:  Manuela Malsy; Bernhard Graf; Anika Bundscherer
Journal:  BMC Pharmacol Toxicol       Date:  2017-12-06       Impact factor: 2.483

Review 9.  Pain management in hemophilia: expert recommendations.

Authors:  Waltraud Stromer; Ingrid Pabinger; Cihan Ay; Richard Crevenna; Josef Donnerer; Clemens Feistritzer; Sophie Hemberger; Rudolf Likar; Florian Sevelda; Katharina Thom; Barbara Wagner; Werner Streif
Journal:  Wien Klin Wochenschr       Date:  2021-03-04       Impact factor: 1.704
  9 in total

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