Influence of mianserin on the antinociceptive effect of morphine, metamizol and indomethacin in mice.

The influence of mianserin (5 or 3.6mgkg(-1)) on antinociceptive effect of morphine (10mgkg(-1)), metamizol (500mgkg(-1)) and indomethacin (10 or 1.4mgkg(-1)) was investigated in a mouse model using the tail-flick and hot-plate tests. All drugs were injected intraperitoneally (i.p.). Mianserin was administered to mice 30min before applying the analgesic drugs. Measurement of nociception was performed within 2h after mianserin administration. The study was further conducted for 14 days with multiple drug doses. The results indicate that mianserin in a single dose increased the antinociceptive effect of metamizol (in the hot-plate and tail-flick tests) and indomethacin (only in the tail-flick test). Mianserin administered for 14 days together with metamizol increased the analgesic effect of the latter drug (in the hot-plate and tail-flick tests). Mianserin applied for 14 days increased the antinociceptive effect of indomethacin (in the tail-flick test).