Samir D Sharma1, Diego Hernando1, Debra E Horng1,2, Scott B Reeder1,2,3,4. 1. Department of Radiology, University of Wisconsin, Madison, Wisconsin, USA. 2. Department of Medical Physics, University of Wisconsin, Madison, Wisconsin, USA. 3. Department of Biomedical Engineering, University of Wisconsin, Madison, Wisconsin, USA. 4. Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.
Abstract
PURPOSE: The purpose of this work was to develop and demonstrate feasibility and initial clinical validation of quantitative susceptibility mapping (QSM) in the abdomen as an imaging biomarker of hepatic iron overload. THEORY AND METHODS: In general, QSM is faced with the challenges of background field removal and dipole inversion. Respiratory motion, the presence of fat, and severe iron overload further complicate QSM in the abdomen. We propose a technique for QSM in the abdomen that addresses these challenges. Data were acquired from 10 subjects without hepatic iron overload and 33 subjects with known or suspected iron overload. The proposed technique was used to estimate the susceptibility map in the abdomen, from which hepatic iron overload was measured. As a reference, spin-echo data were acquired for R2-based LIC estimation. Liver R2* was measured for correlation with liver susceptibility estimates. RESULTS: Correlation between susceptibility and R2-based LIC estimation was R(2) = 0.76 at 1.5 Tesla (T) and R(2) = 0.83 at 3T. Furthermore, high correlation between liver susceptibility and liver R2* (R(2) = 0.94 at 1.5T; R(2) = 0.93 at 3T) was observed. CONCLUSION: We have developed and demonstrated initial validation of QSM in the abdomen as an imaging biomarker of hepatic iron overload.
PURPOSE: The purpose of this work was to develop and demonstrate feasibility and initial clinical validation of quantitative susceptibility mapping (QSM) in the abdomen as an imaging biomarker of hepatic iron overload. THEORY AND METHODS: In general, QSM is faced with the challenges of background field removal and dipole inversion. Respiratory motion, the presence of fat, and severe iron overload further complicate QSM in the abdomen. We propose a technique for QSM in the abdomen that addresses these challenges. Data were acquired from 10 subjects without hepatic iron overload and 33 subjects with known or suspected iron overload. The proposed technique was used to estimate the susceptibility map in the abdomen, from which hepatic iron overload was measured. As a reference, spin-echo data were acquired for R2-based LIC estimation. Liver R2* was measured for correlation with liver susceptibility estimates. RESULTS: Correlation between susceptibility and R2-based LIC estimation was R(2) = 0.76 at 1.5 Tesla (T) and R(2) = 0.83 at 3T. Furthermore, high correlation between liver susceptibility and liver R2* (R(2) = 0.94 at 1.5T; R(2) = 0.93 at 3T) was observed. CONCLUSION: We have developed and demonstrated initial validation of QSM in the abdomen as an imaging biomarker of hepatic iron overload.
Authors: Scott B Reeder; Angel R Pineda; Zhifei Wen; Ann Shimakawa; Huanzhou Yu; Jean H Brittain; Garry E Gold; Christopher H Beaulieu; Norbert J Pelc Journal: Magn Reson Med Date: 2005-09 Impact factor: 4.668
Authors: Huanzhou Yu; Ann Shimakawa; Charles A McKenzie; Ethan Brodsky; Jean H Brittain; Scott B Reeder Journal: Magn Reson Med Date: 2008-11 Impact factor: 4.668
Authors: Jane S Hankins; M Beth McCarville; Ralf B Loeffler; Matthew P Smeltzer; Mihaela Onciu; Fredric A Hoffer; Chin-Shang Li; Winfred C Wang; Russell E Ware; Claudia M Hillenbrand Journal: Blood Date: 2009-03-04 Impact factor: 22.113
Authors: Kofi Deh; Keigo Kawaji; Marjolein Bulk; Louise Van Der Weerd; Emelie Lind; Pascal Spincemaille; Kelly McCabe Gillen; Johan Van Auderkerke; Yi Wang; Thanh D Nguyen Journal: Magn Reson Med Date: 2018-10-04 Impact factor: 4.668