Literature DB >> 25197827

Soluble CD163 is associated with shortened telomere length in HIV-infected patients.

Suman Srinivasa1, Kathleen V Fitch1, Eva Petrow1, Tricia H Burdo2, Kenneth C Williams2, Janet Lo1, Hélène C F Cȏté3, Steven K Grinspoon1.   

Abstract

Telomere length (TL) and immune activation markers were measured in a cohort of HIV-infected (n = 102) and age-matched non-HIV-infected (n = 41) men. TL was significantly shorter in HIV-infected compared with non-HIV-infected subjects (P = 0.04). Univariate analysis revealed a strong inverse relationship of TL to sCD163, and thus, monocyte/macrophage activation, among the HIV group (ρ = -0.30, P = 0.003). In multivariate modeling among the whole group, HIV-positive serostatus (P = 0.06) and sCD163 (P = 0.05) remained predictors of TL controlling for age and smoking status. Our data demonstrate that increased immune activation relates to shorter TL in HIV.

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Year:  2014        PMID： 25197827      PMCID： PMC4213298          DOI： 10.1097/QAI.0000000000000329

Source DB:  PubMed          Journal:  J Acquir Immune Defic Syndr        ISSN： 1525-4135            Impact factor:   3.731


  34 in total

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2.  Association between short leukocyte telomere length and HIV infection in a cohort study: No evidence of a relationship with antiretroviral therapy.

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5.  HIV and aging: time for a new paradigm.

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6.  Human immunodeficiency virus type 1 modulates telomerase activity in peripheral blood lymphocytes.

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7.  Telomere length and risk of incident cancer and cancer mortality.

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8.  Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease.

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Authors:  Rita B Effros; Courtney V Fletcher; Kelly Gebo; Jeffrey B Halter; William R Hazzard; Frances McFarland Horne; Robin E Huebner; Edward N Janoff; Amy C Justice; Daniel Kuritzkes; Susan G Nayfield; Susan F Plaeger; Kenneth E Schmader; John R Ashworth; Christine Campanelli; Charles P Clayton; Beth Rada; Nancy F Woolard; Kevin P High
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10.  Telomere length measurement by a novel monochrome multiplex quantitative PCR method.

Authors:  Richard M Cawthon
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  8 in total

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Authors:  Min Li; Yram Foli; Nana Y Amakye; Taline Klein; Shanmugapriya Selvaraj; Lingeng Lu; Elijah Paintsil
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2.  Early life infection, but not breastfeeding, predicts adult blood telomere lengths in the Philippines.

Authors:  Dan T A Eisenberg; Judith B Borja; M Geoffrey Hayes; Christopher W Kuzawa
Journal:  Am J Hum Biol       Date:  2017-01-25       Impact factor: 1.937

3.  Biomarkers of Aging in HIV-Infected Children on Suppressive Antiretroviral Therapy.

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Journal:  J Acquir Immune Defic Syndr       Date:  2018-08-15       Impact factor: 3.731

4.  Decreases in markers of monocyte/macrophage activation after hepatitis C eradication in HIV/hepatitis C virus coinfected women.

Authors:  Audrey L French; Dara Grennan; Elizabeth Daubert; Eric C Seaberg; Marion Peters; Michael Augenbraun; Margaret Fischl; Seble Kassaye; Ricardo Franco; Mark Kuniholm; Adaora A Adimora; Kimberly Workowski; Kathleen M Weber
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Review 5.  Biological Aging and Immune Senescence in Children with Perinatally Acquired HIV.

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Review 6.  Monocytes in HIV and SIV Infection and Aging: Implications for Inflamm-Aging and Accelerated Aging.

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7.  Myeloid Cells Enriched for a Dendritic Cell Population From People Living With HIV Have Altered Gene Expression Not Restored by Antiretroviral Therapy.

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8.  Subclinical atherosclerosis and immune activation in young HIV-infected patients with telomere shortening.

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  8 in total

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