Min Jung Bae1, Sang Soo Kim2,3, Won Jin Kim2,3, Yang Seon Yi4, Yun Kyung Jeon2,3, Bo Hyun Kim2,3, Byung Joo Lee5, Jin Choon Lee5, In Joo Kim2,3, Soo Geun Wang5, Yong Ki Kim1. 1. Kim Yong Ki Internal Medicine Clinic, Busan, Korea. 2. Department of Internal Medicine, Pusan National University Hospital, Busan, Korea. 3. Biomedical Research Institute, Pusan National University Hospital, Busan, Korea. 4. Department of Internal Medicine, Busan Veterans Hospital, Busan, Korea. 5. Department of Otolaryngology, Pusan National University Hospital, Busan, Korea.
Abstract
BACKGROUND: The purpose of this study was to determine if hyperinsulinemia and/or insulin resistance are/is associated with the prevalence of papillary thyroid cancer (PTC) in Korean women. METHODS: This study included 735 female patients with PTC and 537 female non-PTC control subjects. Multiple logistic regression analysis was performed to evaluate the associations between hyperinsulinemia/insulin resistance and the occurrence of PTC. RESULTS: The prevalence of PTC was significantly correlated with increased insulin, glucose levels, and a high homeostasis model of assessment-insulin resistance (HOMA-IR). The multivariate adjusted odds ratios for the prevalence of PTC in the highest quartile groups for insulin, glucose, and HOMA-IR were 2.88, 9.32, and 4.07 (all p < .001), respectively, compared with the lowest quartile groups. Pathological analyses revealed that increased serum glucose, insulin levels, and a higher HOMA-IR were associated with the multifocality of PTC. CONCLUSION: Hyperinsulinemia and/or insulin resistance may be associated with the development of PTC, but not disease severity in Korean women.
BACKGROUND: The purpose of this study was to determine if hyperinsulinemia and/or insulin resistance are/is associated with the prevalence of papillary thyroid cancer (PTC) in Korean women. METHODS: This study included 735 female patients with PTC and 537 female non-PTC control subjects. Multiple logistic regression analysis was performed to evaluate the associations between hyperinsulinemia/insulin resistance and the occurrence of PTC. RESULTS: The prevalence of PTC was significantly correlated with increased insulin, glucose levels, and a high homeostasis model of assessment-insulin resistance (HOMA-IR). The multivariate adjusted odds ratios for the prevalence of PTC in the highest quartile groups for insulin, glucose, and HOMA-IR were 2.88, 9.32, and 4.07 (all p < .001), respectively, compared with the lowest quartile groups. Pathological analyses revealed that increased serum glucose, insulin levels, and a higher HOMA-IR were associated with the multifocality of PTC. CONCLUSION:Hyperinsulinemia and/or insulin resistance may be associated with the development of PTC, but not disease severity in Korean women.
Authors: Raul Zamora-Ros; Virginie Béraud; Silvia Franceschi; Valerie Cayssials; Konstantinos K Tsilidis; Marie-Christine Boutron-Ruault; Elisabete Weiderpass; Kim Overvad; Anne Tjønneland; Anne K Eriksen; Fabrice Bonnet; Aurélie Affret; Verena Katzke; Tilman Kühn; Heiner Boeing; Antonia Trichopoulou; Elisavet Valanou; Anna Karakatsani; Giovanna Masala; Sara Grioni; Maria Santucci de Magistris; Rosario Tumino; Fulvio Ricceri; Guri Skeie; Christine L Parr; Susana Merino; Elena Salamanca-Fernández; Maria-Dolores Chirlaque; Eva Ardanaz; Pilar Amiano; Martin Almquist; Isabel Drake; Joakim Hennings; Maria Sandström; H B As Bueno-de-Mesquita; Petra H Peeters; Kay-Thee Khaw; Nicholas J Wareham; Julie A Schmidt; Aurora Perez-Cornago; Dagfinn Aune; Elio Riboli; Nadia Slimani; Augustin Scalbert; Isabelle Romieu; Antonio Agudo; Sabina Rinaldi Journal: Int J Cancer Date: 2017-07-24 Impact factor: 7.396