Metal coordination, and metal-ligand redox non-innocence, modulates allosteric C-N bond homolysis in an N-benzyl tetrazine.

Remote coordination of a Ru(hfac)2 moiety to a chelating N-benzyl tetrazine lowers the C-N homolytic bond dissociation enthalpy by approximately 20 kJ mol(-1). The significant bond strength perturbation is believed to arise as a consequence of metal-ligand redox non-innocence.