| Literature DB >> 25194280 |
Qingyi Wei1, Dianke Yu2, Mingbo Liu3, Mengyun Wang4, Miaoqing Zhao5, Ming Liu6, Weihua Jia7, Hongxia Ma8, Jugao Fang9, Wei Xu10, Kexing Chen11, Zhengang Xu12, Jialing Wang13, Linli Tian6, Hua Yuan8, Jiang Chang14, Zhibin Hu8, Lixun Wei14, Ying Huang14, Yaling Han14, Jie Liu12, Demin Han9, Hongbing Shen8, Shiming Yang13, Hong Zheng11, Qinghai Ji15, Duanshu Li15, Wen Tan14, Chen Wu14, Dongxin Lin14.
Abstract
To identify genetic markers for laryngeal squamous cell carcinoma (LSCC), we conducted a genome-wide association study (GWAS) on 993 individuals with LSCC (cases) and 1,995 cancer-free controls from Chinese populations. The most promising variants (association P < 1 × 10(-5)) were then replicated in 3 independent sets including 2,398 cases and 2,804 controls, among which we identified 3 new susceptibility loci at 11q12 (rs174549), 6p21 (rs2857595) and 12q24 (rs10492336). The minor alleles of each of these loci showed protective effects, with odds ratios (95% confidence intervals) of 0.73 (0.68-0.78; P = 1.00 × 10(-20)), 0.78 (0.72-0.84; P = 2.43 × 10(-15)) and 0.71 (0.65-0.77; P = 4.48 × 10(-14)), respectively. None of these variants showed an interaction with smoking or drinking. This is the first GWAS to our knowledge solely on LSCC, and the findings might advance understanding of the etiology of LSCC.Entities:
Mesh：
Year: 2014 PMID： 25194280 DOI： 10.1038/ng.3090
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330