| Literature DB >> 21642993 |
Chen Wu1, Zhibin Hu, Zhonghu He, Weihua Jia, Feng Wang, Yifeng Zhou, Zhihua Liu, Qimin Zhan, Yu Liu, Dianke Yu, Kan Zhai, Jiang Chang, Yan Qiao, Guangfu Jin, Zhe Liu, Yuanyuan Shen, Chuanhai Guo, Jianhua Fu, Xiaoping Miao, Wen Tan, Hongbing Shen, Yang Ke, Yixin Zeng, Tangchun Wu, Dongxin Lin.
Abstract
Esophageal squamous-cell carcinoma (ESCC) is one of the most prevalent cancers worldwide and occurs at a relatively high frequency in China. To identify genetic susceptibility loci for ESCC, we conducted a genome-wide association study on 2,031 individuals with ESCC (cases) and 2,044 controls of Chinese descent using 666,141 autosomal SNPs. We evaluated promising associations in an additional 6,276 cases and 6,165 controls of Chinese descent from different areas of China. We identified seven susceptibility loci on chromosomes 5q11, 6p21, 10q23, 12q24 and 21q22 (ranging from P = 7.48 × 10(-12) to P = 2.44 × 10(-31)); among these loci, 5q11, 6p21 and 21q22 were newly identified. Three variants in high linkage disequilibrium on 12q24 confer their risks to ESCC in a gene-lifestyle interaction manner, with more pronounced risk enhancement seen in tobacco and alcohol users. Furthermore, the identified variants had a cumulative association with ESCC risk (P(trend) = 7.92 × 10(-56)). These findings highlight the involvement of multiple genetic loci and gene-environment interaction in the development of esophageal cancer.Entities:
Mesh：
Year: 2011 PMID： 21642993 DOI： 10.1038/ng.849
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330