| Literature DB >> 25191837 |
Kebo Xie1, Ridao Chen, Jianhua Li, Ruishan Wang, Dawei Chen, Xiaoxiang Dou, Jungui Dai.
Abstract
The catalytic promiscuity of a new glycosyltransferase (UGT73AE1) from Carthamus tinctorius was explored. UGT73AE1 showed the capability to glucosylate a total of 19 structurally diverse types of acceptors and to generate O-, S-, and N-glycosides, making it the first reported trifunctional plant glycosyltransferase. The catalytic reversibility and regioselectivity were observed and modeled in a one-pot reaction transferring a glucose moiety from icariin to emodin. These findings demonstrate the potential versatility of UGT73AE1 in the glycosylation of bioactive natural products.Entities:
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Year: 2014 PMID： 25191837 DOI： 10.1021/ol502380p
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005