Literature DB >> 25190787

Comment on "Local impermeant anions establish the neuronal chloride concentration".

Juha Voipio1, Walter F Boron2, Stephen W Jones2, Ulrich Hopfer2, John A Payne3, Kai Kaila4.   

Abstract

Glykys et al. (Reports, 7 February 2014, p. 670) conclude that, rather than ion transporters, "local impermeant anions establish the neuronal chloride concentration" and thereby determine "the magnitude and direction of GABAAR currents at individual synapses." If this were possible, perpetual ion-motion machines could be constructed. The authors' conclusions conflict with basic thermodynamic principles.
Copyright © 2014, American Association for the Advancement of Science.

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Year:  2014        PMID： 25190787     DOI： 10.1126/science.1252978

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  14 in total

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2.  Tenuous Inhibitory GABAergic Signaling in the Reticular Thalamus.

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Review 4.  Cation-chloride cotransporters in neuronal development, plasticity and disease.

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Review 7.  Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential.

Authors:  Joseph Glykys; Volodymyr Dzhala; Kiyoshi Egawa; Kristopher T Kahle; Eric Delpire; Kevin Staley
Journal:  Trends Neurosci       Date:  2017-04-18       Impact factor: 13.837

8.  Biophysical models reveal the relative importance of transporter proteins and impermeant anions in chloride homeostasis.

Authors:  Christopher B Currin; Richard J Burman; Kira M Düsterwald; Colin J Akerman; Alan R Kay; Joseph V Raimondo
Journal:  Elife       Date:  2018-09-27       Impact factor: 8.140

9.  Spines slow down dendritic chloride diffusion and affect short-term ionic plasticity of GABAergic inhibition.

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Review 10.  Electrodiffusion phenomena in neuroscience: a neglected companion.

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Journal:  Nat Rev Neurosci       Date:  2017-09-19       Impact factor: 34.870
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