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Literature DB >> 35524444

Clarifications regarding bumetanide for neonatal seizures.

Abstract

A recent Phase II randomized, controlled trial of bumetanide as an adjunctive treatment for neonatal seizures showed a robust efficacy signal and no evidence of toxicity. Concerns regarding bumetanide as an adjunctive anticonvulsant are addressed here. An adequately powered multi-institutional trial is needed to accurately determine efficacy.

Entities: Chemical

Keywords: GABA; bumetanide; chloride; neonatal seizures

Mesh：

Substances：

Year: 2022 PMID： 35524444 PMCID： PMC9283319 DOI： 10.1111/epi.17278

Source DB: PubMed Journal: Epilepsia ISSN： 0013-9580 Impact factor: 6.740

65 in total

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Journal: Early Hum Dev Date: 1979-03 Impact factor: 2.079

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Authors: Niamh E Lynch; Nathan J Stevenson; Vicki Livingstone; Brendan P Murphy; Janet M Rennie; Geraldine B Boylan
Journal: Epilepsia Date: 2012-02-06 Impact factor: 5.864

3. European Resuscitation Council Guidelines 2021: Newborn resuscitation and support of transition of infants at birth.

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Journal: Resuscitation Date: 2021-03-24 Impact factor: 5.262

4. Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia.

Authors: Thomas M Hyde; Barbara K Lipska; Towhid Ali; Shiny V Mathew; Amanda J Law; Ochuko E Metitiri; Richard E Straub; Tianzhang Ye; Carlo Colantuoni; Mary M Herman; Llewellyn B Bigelow; Daniel R Weinberger; Joel E Kleinman
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Journal: Exp Neurol Date: 2010-04-18 Impact factor: 5.330

7. Treatment during a vulnerable developmental period rescues a genetic epilepsy.

Authors: Stephan Lawrence Marguet; Vu Thao Quyen Le-Schulte; Andrea Merseburg; Axel Neu; Ronny Eichler; Igor Jakovcevski; Anton Ivanov; Ileana Livia Hanganu-Opatz; Christophe Bernard; Fabio Morellini; Dirk Isbrandt
Journal: Nat Med Date: 2015-11-23 Impact factor: 53.440

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Review 9. Part 5: Neonatal Resuscitation 2020 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care.

Authors: Khalid Aziz; Chair Henry C Lee; Marilyn B Escobedo; Amber V Hoover; Beena D Kamath-Rayne; Vishal S Kapadia; David J Magid; Susan Niermeyer; Georg M Schmölzer; Edgardo Szyld; Gary M Weiner; Myra H Wyckoff; Nicole K Yamada; Jeanette Zaichkin
Journal: Pediatrics Date: 2020-10-21 Impact factor: 7.124

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Authors: Alexey S Pospelov; Tommi Ala-Kurikka; Samu Kurki; Juha Voipio; Kai Kaila
Journal: Epilepsia Date: 2021-06-27 Impact factor: 5.864

1 in total

1. Bumetanide for neonatal seizures: No light in the pharmacokinetic/dynamic tunnel.

Authors: Kai Kaila; Wolfgang Löscher
Journal: Epilepsia Date: 2022-05-26 Impact factor: 6.740

1 in total