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Literature DB >> 25190626

Metformin treatment alters memory function in a mouse model of Alzheimer's disease.

Kacee A DiTacchio¹, Stephen F Heinemann¹, Gustavo Dziewczapolski¹.

Abstract

Metabolic dysfunction exacerbates Alzheimer's disease (AD) incidence and progression. Here we report that activation of the AMPK pathway, a common target in the management of diabetes, results in gender-divergent cognitive effects in a murine model of the disease. Specifically, our results show that activation of AMPK increases memory dysfunction in males but is protective in females, suggesting that gender considerations may constitute an important factor in medical intervention of diabetes as well as AD.

Entities: Chemical

Keywords: AMPK; Alzheimer's disease; metformin; type 2 diabetes mellitus

Mesh：

Substances：

Year: 2015 PMID： 25190626 PMCID： PMC9057391 DOI： 10.3233/JAD-141332

Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472

25 in total

1. Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes.

Authors: Amit Gupta; Bharti Bisht; Chinmoy Sankar Dey
Journal: Neuropharmacology Date: 2011-01-26 Impact factor: 5.250

2. A randomised controlled trial testing the impact of exercise on cognitive symptoms and disability of residents with dementia.

Authors: John Stevens; Mark Killeen
Journal: Contemp Nurse Date: 2006 Feb-Mar Impact factor: 1.787

3. Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study.

Authors: Patrick Imfeld; Michael Bodmer; Susan S Jick; Christoph R Meier
Journal: J Am Geriatr Soc Date: 2012-03-28 Impact factor: 5.562

4. Chronic activation of AMP-activated protein kinase-alpha1 in liver leads to decreased adiposity in mice.

Authors: Jian Yang; Shanna Maika; Lauren Craddock; Judy A King; Zhi-Mei Liu
Journal: Biochem Biophys Res Commun Date: 2008-03-31 Impact factor: 3.575

5. Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver.

Authors: Weiqin Jiang; Zongjian Zhu; Henry J Thompson
Journal: Cancer Res Date: 2008-07-01 Impact factor: 12.701

6. Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease.

Authors: Gustavo Dziewczapolski; Carolina M Glogowski; Eliezer Masliah; Stephen F Heinemann
Journal: J Neurosci Date: 2009-07-08 Impact factor: 6.167

7. Metformin slows down aging and extends life span of female SHR mice.

Authors: Vladimir N Anisimov; Lev M Berstein; Peter A Egormin; Tatiana S Piskunova; Irina G Popovich; Mark A Zabezhinski; Margarita L Tyndyk; Maria V Yurova; Irina G Kovalenko; Tatiana E Poroshina; Anna V Semenchenko
Journal: Cell Cycle Date: 2008-09-11 Impact factor: 4.534

8. Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition.

Authors: A Parachikova; K E Nichol; C W Cotman
Journal: Neurobiol Dis Date: 2008-01-05 Impact factor: 5.996

9. Increased risk of cognitive impairment in patients with diabetes is associated with metformin.

Authors: Eileen M Moore; Alastair G Mander; David Ames; Mark A Kotowicz; Ross P Carne; Henry Brodaty; Michael Woodward; Karyn Boundy; Kathryn A Ellis; Ashley I Bush; Noel G Faux; Ralph Martins; Cassandra Szoeke; Christopher Rowe; David A Watters
Journal: Diabetes Care Date: 2013-09-05 Impact factor: 19.112

10. Continuation of exercise is necessary to inhibit high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice.

Authors: Masato Maesako; Kengo Uemura; Ayana Iwata; Masakazu Kubota; Kiwamu Watanabe; Maiko Uemura; Yasuha Noda; Megumi Asada-Utsugi; Takeshi Kihara; Ryosuke Takahashi; Shun Shimohama; Ayae Kinoshita
Journal: PLoS One Date: 2013-09-04 Impact factor: 3.240

29 in total

1. Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice.

Authors: Joanne S Allard; Evelyn J Perez; Koji Fukui; Priscilla Carpenter; Donald K Ingram; Rafael de Cabo
Journal: Behav Brain Res Date: 2015-12-14 Impact factor: 3.332

Review 2. New views and possibilities of antidiabetic drugs in treating and/or preventing mild cognitive impairment and Alzheimer's Disease.

Authors: Kai Long Zhong; Fang Chen; Hao Hong; Xuan Ke; Yang Ge Lv; Su Su Tang; Yu Bing Zhu
Journal: Metab Brain Dis Date: 2018-04-06 Impact factor: 3.584

3. Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease.

Authors: Dan Liu; Hui Tang; Xin-Yan Li; Man-Fei Deng; Na Wei; Xiong Wang; Ya-Fan Zhou; Ding-Qi Wang; Peng Fu; Jian-Zhi Wang; Sébastien S Hébert; Jian-Guo Chen; Youming Lu; Ling-Qiang Zhu
Journal: Mol Ther Date: 2017-02-13 Impact factor: 11.454

Metformin treatment alters memory function in a mouse model of Alzheimer's disease.

1. Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer's-like changes.

2. A randomised controlled trial testing the impact of exercise on cognitive symptoms and disability of residents with dementia.

3. Metformin, other antidiabetic drugs, and risk of Alzheimer's disease: a population-based case-control study.

4. Chronic activation of AMP-activated protein kinase-alpha1 in liver leads to decreased adiposity in mice.

5. Dietary energy restriction modulates the activity of AMP-activated protein kinase, Akt, and mammalian target of rapamycin in mammary carcinomas, mammary gland, and liver.

6. Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease.

7. Metformin slows down aging and extends life span of female SHR mice.

8. Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition.

9. Increased risk of cognitive impairment in patients with diabetes is associated with metformin.

10. Continuation of exercise is necessary to inhibit high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice.

1. Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice.

Review 2. New views and possibilities of antidiabetic drugs in treating and/or preventing mild cognitive impairment and Alzheimer's Disease.

3. Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease.

4. Electroacupuncture improves cognitive deficits associated with AMPK activation in SAMP8 mice.

5. Metformin and Sulfonylurea Use and Risk of Incident Dementia.

6. AMPK Signaling in the Dorsal Hippocampus Negatively Regulates Contextual Fear Memory Formation.

7. Drug synergy as a strategy for compression of morbidity in a Caenorhabditis elegans model of Alzheimer's disease.

Review 8. Role of insulin receptor substance-1 modulating PI3K/Akt insulin signaling pathway in Alzheimer's disease.

Review 9. Exercise mimetics: harnessing the therapeutic effects of physical activity.

Review 10. Beneficial Effects of Metformin on the Central Nervous System, with a Focus on Epilepsy and Lafora Disease.