CONTEXT: Metabolic syndrome (MetS) clusters risk factors for age-related conditions including cardiovascular disease and diabetes. Shorter telomere length (TL), a cellular marker for biological age, may predict an individual's deteriorating metabolic condition. OBJECTIVE: We examined whether shorter baseline TL is associated with a worse metabolic profile and with less favorable trajectories of MetS components over a 6-year follow-up. DESIGN AND SETTING: PARTICIPANTS were part of The Netherlands Study of Depression and Anxiety, an ongoing prospective cohort study with 6-year follow-up. PARTICIPANTS: This study included 2848 participants age 18-65 years. MAIN OUTCOME MEASURES: Baseline TL from leukocytes was determined using qPCR and MetS components (waist circumference, triglycerides, high-density lipoprotein [HDL] cholesterol, systolic blood pressure, and fasting glucose) were determined at baseline, and after 2 and 6 years. Cross-sectional and longitudinal analyses were adjusted for relevant sociodemographic, lifestyle, and health factors. RESULTS: Shorter baseline TL was cross-sectionally associated with HDL (β = -0.016, SE = 0.008, P = .05), waist circumference (β = 0.647, SE = 0.238, P = .007), triglycerides (β = 0.038, SE = 0.009, P < .001), and fasting glucose (β = 0.011, SE = 0.003, P < .001), as well as with the total number of MetS components (β = 0.075, SE = 0.023, P = .001) and the presence of MetS (OR = 1.19; 95% CI, 1.07-1.33; P = .002). Although baseline differences progressively reduced over time, shorter baseline TL was still significantly associated with unfavorable scores of most MetS components at the 2- or 6-year follow-up. CONCLUSIONS: Cellular aging, as assessed by TL, is associated with a higher metabolic risk profile, which remains unfavorable even after a period of 6 years. These findings suggest that cellular aging might play a role in the onset of various aging-related somatic diseases via its effect on metabolic alterations.
CONTEXT: Metabolic syndrome (MetS) clusters risk factors for age-related conditions including cardiovascular disease and diabetes. Shorter telomere length (TL), a cellular marker for biological age, may predict an individual's deteriorating metabolic condition. OBJECTIVE: We examined whether shorter baseline TL is associated with a worse metabolic profile and with less favorable trajectories of MetS components over a 6-year follow-up. DESIGN AND SETTING:PARTICIPANTS were part of The Netherlands Study of Depression and Anxiety, an ongoing prospective cohort study with 6-year follow-up. PARTICIPANTS: This study included 2848 participants age 18-65 years. MAIN OUTCOME MEASURES: Baseline TL from leukocytes was determined using qPCR and MetS components (waist circumference, triglycerides, high-density lipoprotein [HDL] cholesterol, systolic blood pressure, and fasting glucose) were determined at baseline, and after 2 and 6 years. Cross-sectional and longitudinal analyses were adjusted for relevant sociodemographic, lifestyle, and health factors. RESULTS: Shorter baseline TL was cross-sectionally associated with HDL (β = -0.016, SE = 0.008, P = .05), waist circumference (β = 0.647, SE = 0.238, P = .007), triglycerides (β = 0.038, SE = 0.009, P < .001), and fasting glucose (β = 0.011, SE = 0.003, P < .001), as well as with the total number of MetS components (β = 0.075, SE = 0.023, P = .001) and the presence of MetS (OR = 1.19; 95% CI, 1.07-1.33; P = .002). Although baseline differences progressively reduced over time, shorter baseline TL was still significantly associated with unfavorable scores of most MetS components at the 2- or 6-year follow-up. CONCLUSIONS: Cellular aging, as assessed by TL, is associated with a higher metabolic risk profile, which remains unfavorable even after a period of 6 years. These findings suggest that cellular aging might play a role in the onset of various aging-related somatic diseases via its effect on metabolic alterations.
Authors: Andrea L Roberts; Karestan C Koenen; Qixuan Chen; Paola Gilsanz; Susan M Mason; Jennifer Prescott; Andrew Ratanatharathorn; Eric B Rimm; Jennifer A Sumner; Ashley Winning; Immaculata De Vivo; Laura D Kubzansky Journal: Depress Anxiety Date: 2017-04-05 Impact factor: 6.505
Authors: Elizabeth E Hatch; Amelia K Wesselink; Kristen A Hahn; James J Michiel; Ellen M Mikkelsen; Henrik Toft Sorensen; Kenneth J Rothman; Lauren A Wise Journal: Epidemiology Date: 2018-05 Impact factor: 4.822
Authors: Dóra Révész; Josine E Verhoeven; Martin Picard; Jue Lin; Stephen Sidney; Elissa S Epel; Brenda W J H Penninx; Eli Puterman Journal: J Clin Endocrinol Metab Date: 2018-01-01 Impact factor: 5.958
Authors: Dhuha M B AlDehaini; Suzanne A Al-Bustan; Zainab Hasan Abdulla Malalla; Muhalab E Ali; Mai Sater; Hayder A Giha Journal: Cardiovasc Endocrinol Metab Date: 2020-09-03
Authors: Esmée M Bijnens; Catherine Derom; Evert Thiery; Dries S Martens; Ruth J F Loos; Steven Weyers; Tim S Nawrot Journal: Sci Rep Date: 2021-06-11 Impact factor: 4.379