Literature DB >> 25188336

Amphirionin-4 with potent proliferation-promoting activity on bone marrow stromal cells from a marine dinoflagellate amphidinium species.

Mika Minamida1, Keiko Kumagai, Dana Ulanova, Mai Akakabe, Yuko Konishi, Akira Tominaga, Hidenori Tanaka, Masayuki Tsuda, Eri Fukushi, Jun Kawabata, Atsunori Masuda, Masashi Tsuda.   

Abstract

A linear polyketide, amphirionin-4 (1), has been isolated from cultivated algal cells of the marine dinoflagellate Amphidinium species. The structure was elucidated on the basis of detailed analyses of 1D and 2D NMR data, and the absolute configurations of C-4 and C-8 were determined using the modified Mosher's method. Amphirionin-4 (1) exhibited extremely potent proliferation-promoting activity on murine bone marrow stromal ST-2 cells (950% promotion) at a concentration of 0.1 ng/mL.

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Year:  2014        PMID： 25188336     DOI： 10.1021/ol5023504

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  10 in total

1.  Iriomoteolides-9a and 11a: two new odd-numbered macrolides from the marine dinoflagellate Amphidinium species.

Authors:  Keiko Kumagai; Masayuki Tsuda; Eri Fukushi; Jun Kawabata; Atsunori Masuda; Masashi Tsuda
Journal:  J Nat Med       Date:  2017-03-02       Impact factor: 2.343

2.  Lewis Acid-Catalyzed Vinyl Acetal Rearrangement of 4,5-Dihydro-1,3-dioxepines: Stereoselective Synthesis of cis- and trans-2,3-Disubstituted Tetrahydrofurans.

Authors:  Arun K Ghosh; Miranda R Belcher
Journal:  J Org Chem       Date:  2020-08-05       Impact factor: 4.354

3.  Enantioselective Total Synthesis of (+)-Amphirionin-4.

Authors:  Arun K Ghosh; Prasanth R Nyalapatla
Journal:  Org Lett       Date:  2016-04-26       Impact factor: 6.005

4.  Total syntheses of both enantiomers of amphirionin 4: A chemoenzymatic based strategy for functionalized tetrahydrofurans.

Authors:  Arun K Ghosh; Prasanth R Nyalapatla
Journal:  Tetrahedron       Date:  2017-02-17       Impact factor: 2.457

Review 5.  Phytoplankton Toxins and Their Potential Therapeutic Applications: A Journey toward the Quest for Potent Pharmaceuticals.

Authors:  Biswajita Pradhan; Jang-Seu Ki
Journal:  Mar Drugs       Date:  2022-04-18       Impact factor: 6.085

6.  De novo transcriptome of the cosmopolitan dinoflagellate Amphidinium carterae to identify enzymes with biotechnological potential.

Authors:  Chiara Lauritano; Daniele De Luca; Alberto Ferrarini; Carla Avanzato; Andrea Minio; Francesco Esposito; Adrianna Ianora
Journal:  Sci Rep       Date:  2017-09-15       Impact factor: 4.379

Review 7.  Biotechnological and Pharmacological Applications of Biotoxins and Other Bioactive Molecules from Dinoflagellates.

Authors:  Joana Assunção; A Catarina Guedes; F Xavier Malcata
Journal:  Mar Drugs       Date:  2017-12-20       Impact factor: 5.118

Review 8.  Bioactive Compounds from Marine Organisms: Potential for Bone Growth and Healing.

Authors:  Matthew A Carson; Susan A Clarke
Journal:  Mar Drugs       Date:  2018-09-18       Impact factor: 5.118

Review 9.  Marine Pharmacology in 2014-2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action.

Authors:  Alejandro M S Mayer; Aimee J Guerrero; Abimael D Rodríguez; Orazio Taglialatela-Scafati; Fumiaki Nakamura; Nobuhiro Fusetani
Journal:  Mar Drugs       Date:  2019-12-19       Impact factor: 5.118

10.  Isolation and Structural Elucidation of New Amphidinol Analogues from Amphidinium carterae Cultivated in a Pilot-Scale Photobioreactor.

Authors:  Adrián Morales-Amador; Alejandro Molina-Miras; Lorenzo López-Rosales; Asterio Sánchez-Mirón; Francisco García-Camacho; María L Souto; José J Fernández
Journal:  Mar Drugs       Date:  2021-07-29       Impact factor: 5.118
  10 in total

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