Sourabh Chand1, Amy Jayne McKnight, Richard Borrows. 1. aDepartment of Nephrology and Kidney Transplantation, Queen Elizabeth Hospital Birmingham bCentre for Translational Inflammation Research, University of Birmingham, Birmingham, UK cRegional Nephrology Unit, Belfast City Hospital, Belfast, Northern Ireland.
Abstract
PURPOSE OF REVIEW: Gene polymorphism studies are growing at a quasiexponential rate and aim to improve immediate and long-term outcomes in renal transplantation. This review highlights recent evidence and potential future directions for genetic research studies. RECENT FINDINGS: Studies are largely based on immunity, inflammation and pharmacogenetics, investigating mostly 'surrogate' outcomes with sometimes conflicting results. However, the last 12 months has also heralded the emergence of important genome-wide association studies on transplantation, more robust replicated multicentre analyses of candidate gene variants, meta-analyses, and an increasing interest in copy number variation and donor genetics. SUMMARY: These studies set the scene for further investigation, aiming to understand pathways of disease and biomarkers of risk, and are leading to a greater understanding of the biology of transplantation. Future studies will require focus on donor : recipient and gene : environment interactions, and an integrated approach of 'transplantomics' to evaluate long-term outcomes in multinational collaborations.
PURPOSE OF REVIEW: Gene polymorphism studies are growing at a quasiexponential rate and aim to improve immediate and long-term outcomes in renal transplantation. This review highlights recent evidence and potential future directions for genetic research studies. RECENT FINDINGS: Studies are largely based on immunity, inflammation and pharmacogenetics, investigating mostly 'surrogate' outcomes with sometimes conflicting results. However, the last 12 months has also heralded the emergence of important genome-wide association studies on transplantation, more robust replicated multicentre analyses of candidate gene variants, meta-analyses, and an increasing interest in copy number variation and donor genetics. SUMMARY: These studies set the scene for further investigation, aiming to understand pathways of disease and biomarkers of risk, and are leading to a greater understanding of the biology of transplantation. Future studies will require focus on donor : recipient and gene : environment interactions, and an integrated approach of 'transplantomics' to evaluate long-term outcomes in multinational collaborations.
Authors: Abraham Shaked; Bao-Li Loza; Elisabet Van Loon; Kim M Olthoff; Weihua Guan; Pamala A Jacobson; Andrew Zhu; Claire E Fishman; Hui Gao; William S Oetting; Ajay K Israni; Giuliano Testa; James Trotter; Goran Klintmalm; Maarten Naesens; Sumeet K Asrani; Brendan J Keating Journal: Nat Med Date: 2022-04-07 Impact factor: 87.241
Authors: Karolina Kłoda; Artur Mierzecki; Leszek Domański; Ewa Borowiecka; Krzysztof Safranow; Andrzej Ciechanowicz; Kazimierz Ciechanowski Journal: Med Sci Monit Date: 2017-04-14
Authors: Maria P Hernandez-Fuentes; Christopher Franklin; Irene Rebollo-Mesa; Jennifer Mollon; Florence Delaney; Esperanza Perucha; Caragh Stapleton; Richard Borrows; Catherine Byrne; Gianpiero Cavalleri; Brendan Clarke; Menna Clatworthy; John Feehally; Susan Fuggle; Sarah A Gagliano; Sian Griffin; Abdul Hammad; Robert Higgins; Alan Jardine; Mary Keogan; Timothy Leach; Iain MacPhee; Patrick B Mark; James Marsh; Peter Maxwell; William McKane; Adam McLean; Charles Newstead; Titus Augustine; Paul Phelan; Steve Powis; Peter Rowe; Neil Sheerin; Ellen Solomon; Henry Stephens; Raj Thuraisingham; Richard Trembath; Peter Topham; Robert Vaughan; Steven H Sacks; Peter Conlon; Gerhard Opelz; Nicole Soranzo; Michael E Weale; Graham M Lord Journal: Am J Transplant Date: 2018-02-01 Impact factor: 8.086
Authors: Mehdi Maanaoui; Rémi Lenain; Aghilès Hamroun; Cynthia Van der Hauwaert; Benjamin Lopez; Jean-Baptiste Gibier; Marie Frimat; Grégoire Savary; Benjamin Hennart; Romain Larrue; Nicolas Pottier; Franck Broly; François Provôt; Marc Hazzan; François Glowacki; Christelle Cauffiez Journal: Sci Rep Date: 2019-10-29 Impact factor: 4.379