Literature DB >> 2518681

Should the costs of development inhibit research into new antihypertensive drugs?

J I Robertson1.   

Abstract

Although hypertensive therapy has had spectacular successes, there is now an important trend away from mere control of blood pressure to the attempt to normalize the cardiac and vascular accompaniments of the disease, such as left ventricular hypertrophy and medial hypertrophy of resistance arterioles. New agents may need to be developed to cope with these specific aims. The costs of development should not inhibit these important goals.

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Year:  1989        PMID: 2518681     DOI: 10.1007/bf01857627

Source DB:  PubMed          Journal:  Cardiovasc Drugs Ther        ISSN: 0920-3206            Impact factor:   3.727


  14 in total

1.  J curve relation between diastolic blood pressure and myocardial infarction.

Authors:  L Hansson
Journal:  BMJ       Date:  1989-01-07

2.  Coronary flow reserve and the J curve.

Authors:  J M Cruickshank
Journal:  BMJ       Date:  1989-02-18

3.  Hypertension and coronary risk: possible adverse effects of antihypertensive drugs.

Authors:  J I Robertson
Journal:  Am Heart J       Date:  1987-10       Impact factor: 4.749

Review 4.  The large studies in hypertension: what have they shown?

Authors:  J I Robertson
Journal:  Br J Clin Pharmacol       Date:  1987       Impact factor: 4.335

5.  Critical comments on recent literature. The J curve and other problems with therapy.

Authors:  N M Kaplan
Journal:  Am J Hypertens       Date:  1989-02       Impact factor: 2.689

Review 6.  Hypertension and its treatment in the elderly.

Authors:  J I Robertson
Journal:  Clin Exp Hypertens A       Date:  1989

7.  MRC trial of treatment of mild hypertension: principal results. Medical Research Council Working Party.

Authors: 
Journal:  Br Med J (Clin Res Ed)       Date:  1985-07-13

8.  Benefits and potential harm of lowering high blood pressure.

Authors:  J M Cruickshank; J M Thorp; F J Zacharias
Journal:  Lancet       Date:  1987-03-14       Impact factor: 79.321

9.  Coronary flow reserve and the J curve relation between diastolic blood pressure and myocardial infarction.

Authors:  J M Cruickshank
Journal:  BMJ       Date:  1988-11-12

10.  Mortality in patients of the Glasgow Blood Pressure Clinic.

Authors:  C G Isles; L M Walker; G D Beevers; I Brown; H L Cameron; J Clarke; V Hawthorne; D Hole; A F Lever; J W Robertson
Journal:  J Hypertens       Date:  1986-04       Impact factor: 4.844

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  2 in total

Review 1.  Newer beta blockers and the treatment of hypertension.

Authors:  D McAreavey; R Vermeulen; J I Robertson
Journal:  Cardiovasc Drugs Ther       Date:  1991-06       Impact factor: 3.727

Review 2.  Guidelines for the treatment of hypertension: a critical review.

Authors:  J I Robertson
Journal:  Cardiovasc Drugs Ther       Date:  1994-08       Impact factor: 3.727

  2 in total

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