Literature DB >> 25186376

A dynamic collimation system for penumbra reduction in spot-scanning proton therapy: proof of concept.

Daniel E Hyer1, Patrick M Hill1, Dongxu Wang1, Blake R Smith1, Ryan T Flynn1.   

Abstract

PURPOSE: In the absence of a collimation system the lateral penumbra of spot scanning (SS) dose distributions delivered by low energy proton beams is highly dependent on the spot size. For current commercial equipment, spot size increases with decreasing proton energy thereby reducing the benefit of the SS technique. This paper presents a dynamic collimation system (DCS) for sharpening the lateral penumbra of proton therapy dose distributions delivered by SS.
METHODS: The collimation system presented here exploits the property that a proton pencil beam used for SS requires collimation only when it is near the target edge, enabling the use of trimmers that are in motion at times when the pencil beam is away from the target edge. The device consists of two pairs of parallel nickel trimmer blades of 2 cm thickness and dimensions of 2 cm×18 cm in the beam's eye view. The two pairs of trimmer blades are rotated 90° relative to each other to form a rectangular shape. Each trimmer blade is capable of rapid motion in the direction perpendicular to the central beam axis by means of a linear motor, with maximum velocity and acceleration of 2.5 m/s and 19.6 m/s2, respectively. The blades travel on curved tracks to match the divergence of the proton source. An algorithm for selecting blade positions is developed to minimize the dose delivered outside of the target, and treatment plans are created both with and without the DCS.
RESULTS: The snout of the DCS has outer dimensions of 22.6×22.6 cm2 and is capable of delivering a minimum treatment field size of 15×15 cm2. Using currently available components, the constructed system would weigh less than 20 kg. For irregularly shaped fields, the use of the DCS reduces the mean dose outside of a 2D target of 46.6 cm2 by approximately 40% as compared to an identical plan without collimation. The use of the DCS increased treatment time by 1-3 s per energy layer.
CONCLUSIONS: The spread of the lateral penumbra of low-energy SS proton treatments may be greatly reduced with the use of this system at the cost of only a small penalty in delivery time.

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Mesh:

Year:  2014        PMID: 25186376     DOI: 10.1118/1.4837155

Source DB:  PubMed          Journal:  Med Phys        ISSN: 0094-2405            Impact factor:   4.071


  32 in total

1.  Technical Note: Optimization of spot and trimmer position during dynamically collimated proton therapy.

Authors:  Blake R Smith; Daniel E Hyer; Ryan T Flynn; Wesley S Culberson
Journal:  Med Phys       Date:  2019-03-05       Impact factor: 4.071

2.  Technical Note: A treatment plan comparison between dynamic collimation and a fixed aperture during spot scanning proton therapy for brain treatment.

Authors:  Blake Smith; Edgar Gelover; Alexandra Moignier; Dongxu Wang; Ryan T Flynn; Liyong Lin; Maura Kirk; Tim Solberg; Daniel E Hyer
Journal:  Med Phys       Date:  2016-08       Impact factor: 4.071

3.  Toward improved target conformity for two spot scanning proton therapy delivery systems using dynamic collimation.

Authors:  Alexandra Moignier; Edgar Gelover; Blake R Smith; Dongxu Wang; Ryan T Flynn; Maura L Kirk; Liyong Lin; Timothy D Solberg; Alexander Lin; Daniel E Hyer
Journal:  Med Phys       Date:  2016-03       Impact factor: 4.071

4.  Experimental and Monte Carlo characterization of a dynamic collimation system prototype for pencil beam scanning proton therapy.

Authors:  Blake R Smith; Mark Pankuch; Daniel E Hyer; Wesley S Culberson
Journal:  Med Phys       Date:  2020-09-09       Impact factor: 4.071

5.  Trimmer sequencing time minimization during dynamically collimated proton therapy using a colony of cooperating agents.

Authors:  Blake R Smith; Daniel E Hyer; Ryan T Flynn; Patrick M Hill; Wesley S Culberson
Journal:  Phys Med Biol       Date:  2019-10-21       Impact factor: 3.609

Review 6.  Empowering Intensity Modulated Proton Therapy Through Physics and Technology: An Overview.

Authors:  Radhe Mohan; Indra J Das; Clifton C Ling
Journal:  Int J Radiat Oncol Biol Phys       Date:  2017-10-01       Impact factor: 7.038

Review 7.  Proton therapy delivery: what is needed in the next ten years?

Authors:  Andries N Schreuder; Jacob Shamblin
Journal:  Br J Radiol       Date:  2019-11-14       Impact factor: 3.039

8.  A method for modeling laterally asymmetric proton beamlets resulting from collimation.

Authors:  Edgar Gelover; Dongxu Wang; Patrick M Hill; Ryan T Flynn; Mingcheng Gao; Steve Laub; Mark Pankuch; Daniel E Hyer
Journal:  Med Phys       Date:  2015-03       Impact factor: 4.071

9.  Design of a focused collimator for proton therapy spot scanning using Monte Carlo methods.

Authors:  Theodore J Geoghegan; Nicholas P Nelson; Ryan T Flynn; Patrick M Hill; Suresh Rana; Daniel E Hyer
Journal:  Med Phys       Date:  2020-04-06       Impact factor: 4.071

10.  An investigation into the robustness of dynamically collimated proton therapy treatments.

Authors:  Blake R Smith; Daniel E Hyer; Wesley S Culberson
Journal:  Med Phys       Date:  2020-05-16       Impact factor: 4.071

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