Nurhazirah Azmi1, Puziah Hashim1, Dzulkifly M Hashim1, Normala Halimoon2, Nik Muhamad Nik Majid3. 1. Halal Products Research Institute, University Putra Malaysia, Putra Infoport, 43400 Upm Serdang, Selangor Darul Ehsan, Malaysia. 2. Faculty of Environmental Studies, University Putra Malaysia 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia. 3. Faculty of Forestry, University Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia.
Abstract
OBJECTIVE: To examine whether earthworms of Eisenia fetida, Lumbricus rubellus and Eudrilus eugeniae extracts have elastase, tyrosinase and matrix metalloproteinase-1 (MMP-1) inhibitory activity. METHODS: The earthworms extract was screened for elastase, tyrosinase and MMP-1 inhibitory activity and compared with the positive controls. It was also evaluated for whitening and anti-wrinkle capacity. RESULTS: The extract showed significantly (P<0.05) good elastase and tyrosinase inhibition and excellent MMP-1 inhibition compared to N-Isobutyl-N-(4-methoxyphenylsulfonyl)-glycylhydroxamic acid. CONCLUSIONS: Earthworms extract showed effective inhibition of tyrosinase, elastase and MMP-1 activities. Therefore, this experiment further rationalizes the traditional use of this worm extracts which may be useful as an anti-wrinkle agent.
OBJECTIVE: To examine whether earthworms of Eisenia fetida, Lumbricus rubellus and Eudrilus eugeniae extracts have elastase, tyrosinase and matrix metalloproteinase-1 (MMP-1) inhibitory activity. METHODS: The earthworms extract was screened for elastase, tyrosinase and MMP-1 inhibitory activity and compared with the positive controls. It was also evaluated for whitening and anti-wrinkle capacity. RESULTS: The extract showed significantly (P<0.05) good elastase and tyrosinase inhibition and excellent MMP-1 inhibition compared to N-Isobutyl-N-(4-methoxyphenylsulfonyl)-glycylhydroxamic acid. CONCLUSIONS:Earthworms extract showed effective inhibition of tyrosinase, elastase and MMP-1 activities. Therefore, this experiment further rationalizes the traditional use of this worm extracts which may be useful as an anti-wrinkle agent.
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