OBJECTIVE: To test two water soluble extracts (aqueous and ethanolic) obtained from the leaves of Vitex doniana in normal and streptozotocin-induced diabetic rats for their effects on pancreatic endocrine tissues and serum marker enzymes for a period of 21 d. METHODS: A total of 55 rats divided into 11 groups of 5 rats each were assigned into diabetic and non-diabetic groups and followed by a daily administration of ethanolic and aqueous extracts for 21 d. Group 1 was the normal control while group 7 was treated with standard drug. RESULTS: The histopathological studies of the diabetic rats indicated increase in the volume density of islets, percent of β-cells and size of islet in the groups that received the plant extracts, which suggested regeneration of β-cells along with β-cells repairs, as compared with the non-treated diabetic control which showed complete degeneration of the islet cells. There was significant reduction (P<0.05) in the serum activities of marker enzymes, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase in diabetes treated rats, whereas an insignificant increase (P>0.01) in the serum activities of marker enzymes was observed for non-diabetic treated rats. Results of total bilirubin, direct bilirubin and unconjugated bilirubin showed that diabetic control group was significantly higher (P<0.05) in total bilirubin and unconjugated bilirubin compared with treated groups while non-diabetic treated groups showed no significant increase (P>0.01) in total bilirubin and direct bilirubin compared with the normal control. CONCLUSION: This herbal therapy appears to bring about repair/regeneration of the endocrine pancreas and hepatic cells protection in the diabetic rat.
OBJECTIVE: To test two water soluble extracts (aqueous and ethanolic) obtained from the leaves of Vitex doniana in normal and streptozotocin-induced diabeticrats for their effects on pancreatic endocrine tissues and serum marker enzymes for a period of 21 d. METHODS: A total of 55 rats divided into 11 groups of 5 rats each were assigned into diabetic and non-diabetic groups and followed by a daily administration of ethanolic and aqueous extracts for 21 d. Group 1 was the normal control while group 7 was treated with standard drug. RESULTS: The histopathological studies of the diabeticrats indicated increase in the volume density of islets, percent of β-cells and size of islet in the groups that received the plant extracts, which suggested regeneration of β-cells along with β-cells repairs, as compared with the non-treated diabetic control which showed complete degeneration of the islet cells. There was significant reduction (P<0.05) in the serum activities of marker enzymes, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase in diabetes treated rats, whereas an insignificant increase (P>0.01) in the serum activities of marker enzymes was observed for non-diabetic treated rats. Results of total bilirubin, direct bilirubin and unconjugated bilirubin showed that diabetic control group was significantly higher (P<0.05) in total bilirubin and unconjugated bilirubin compared with treated groups while non-diabetic treated groups showed no significant increase (P>0.01) in total bilirubin and direct bilirubin compared with the normal control. CONCLUSION: This herbal therapy appears to bring about repair/regeneration of the endocrine pancreas and hepatic cells protection in the diabeticrat.
Authors: Sunday E Atawodi; Joy C Atawodi; Gabriel A Idakwo; Beate Pfundstein; Roswitha Haubner; Gerd Wurtele; Helmut Bartsch; Robert W Owen Journal: J Med Food Date: 2010-06 Impact factor: 2.786
Authors: Tim Strate; Oliver Mann; Helge Kleinhans; Skelkim Rusani; Claus Schneider; Emre Yekebas; Marc Freitag; Thomas Standl; Christian Bloechle; Jakob R Izbicki Journal: Pancreas Date: 2005-04 Impact factor: 3.327
Authors: Jennifer B Moss; Punita Koustubhan; Melanie Greenman; Michael J Parsons; Ingrid Walter; Larry G Moss Journal: Diabetes Date: 2009-06-02 Impact factor: 9.461