| Literature DB >> 25182023 |
Dov B Ballak1, Janna A van Diepen1, Alexander R Moschen2, Henry J Jansen1, Anneke Hijmans1, Gert-Jan Groenhof1, Floris Leenders1, Philip Bufler2, Mark V Boekschoten3, Michael Müller3, Sander Kersten3, Suzhao Li4, SooHyun Kim5, Hadar Eini6, Eli C Lewis6, Leo A B Joosten1, Herbert Tilg7, Mihai G Netea1, Cees J Tack1, Charles A Dinarello8, Rinke Stienstra9.
Abstract
Cytokines of the IL-1 family are important modulators of obesity-induced inflammation and the development of systemic insulin resistance. Here we show that IL-1 family member IL-37, recently characterized as an anti-inflammatory cytokine, ameliorates obesity-induced inflammation and insulin resistance. Mice transgenic for human IL-37 (IL-37tg) exhibit reduced numbers of adipose tissue macrophages, increased circulating levels of adiponectin and preserved glucose tolerance and insulin sensitivity after 16 weeks of HFD. In vitro treatment of adipocytes with recombinant IL-37 reduces adipogenesis and activates AMPK signalling. In humans, elevated steady-state IL-37 adipose tissue mRNA levels are positively correlated with insulin sensitivity and a lower inflammatory status of the adipose tissue. These findings reveal IL-37 as an important anti-inflammatory modulator during obesity-induced inflammation and insulin resistance in both mice and humans, and suggest that IL-37 is a potential target for the treatment of obesity-induced insulin resistance and type 2 diabetes.Entities:
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Year: 2014 PMID： 25182023 DOI： 10.1038/ncomms5711
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919