Literature DB >> 25181577

SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL 2-THIO DERIVATIVES OF ATP.

J Zimmet1, L Järlebark1, T Hammarberg1, P J M van Galen2, K A Jacobson2, E Heilbronn1.   

Abstract

2-Alkylthio analogues of adenosine 5'-triphosphate were synthesized and evaluated as P2y purinoceptor agonists. ATP and analogues transiently increased intracellular Ca2+ levels in C6 glioma cells and in skeletal muscle derived myotubes in culture. Most derivatives were resistant to stepwise dephosphorylation by ecto-ATPases.

Entities:  

Year:  1993        PMID： 25181577      PMCID： PMC4149227          DOI： 10.1080/07328319308016190

Source DB:  PubMed          Journal:  Nucleosides Nucleotides        ISSN： 0732-8311


  21 in total

1.  Platelet aggregation inhibitors. IX. Chemical transformation of adenosine into 2-thioadenosine derivatives.

Authors:  K Kikugawa; H Suehiro; R Yanase; A Aoki
Journal:  Chem Pharm Bull (Tokyo)       Date:  1977-08       Impact factor: 1.645

2.  ATP-induced cation influx in myotubes is additive to cholinergic agonist action.

Authors:  J Häggblad; H Eriksson; E Heilbronn
Journal:  Acta Physiol Scand       Date:  1985-11

3.  Adenosine triphosphate-activated inward current in isolated smooth muscle cells from rat vas deferens.

Authors:  K Nakazawa; N Matsuki
Journal:  Pflugers Arch       Date:  1987-08       Impact factor: 3.657

Review 4.  Biochemical properties of isolated transverse tubular membranes.

Authors:  R A Sabbadini; A S Dahms
Journal:  J Bioenerg Biomembr       Date:  1989-04       Impact factor: 2.945

5.  Extracellular ATP activates polyphosphoinositide breakdown and Ca2+ mobilization in Ehrlich ascites tumor cells.

Authors:  G R Dubyak
Journal:  Arch Biochem Biophys       Date:  1986-02-15       Impact factor: 4.013

6.  P2-purinoceptor-stimulated phosphoinositide turnover in chick myotubes. Calcium mobilization and the role of guanyl nucleotide-binding proteins.

Authors:  J Häggblad; E Heilbronn
Journal:  FEBS Lett       Date:  1988-08-01       Impact factor: 4.124

7.  Comparison of P2 purinergic receptors of aortic endothelial cells with those of adrenal medulla: evidence for heterogeneity of receptor subtype and of inositol phosphate response.

Authors:  D J Allsup; M R Boarder
Journal:  Mol Pharmacol       Date:  1990-07       Impact factor: 4.436

8.  Differentiated rat glial cell strain in tissue culture.

Authors:  P Benda; J Lightbody; G Sato; L Levine; W Sweet
Journal:  Science       Date:  1968-07-26       Impact factor: 47.728

9.  Involvement of inositol 1,4,5-trisphosphate and calcium in the action of adenine nucleotides on aortic endothelial cells.

Authors:  S Pirotton; E Raspe; D Demolle; C Erneux; J M Boeynaems
Journal:  J Biol Chem       Date:  1987-12-25       Impact factor: 5.157

10.  Guanine nucleotide-sensitive interaction of a radiolabeled agonist with a phospholipase C-linked P2y-purinergic receptor.

Authors:  C L Cooper; A J Morris; T K Harden
Journal:  J Biol Chem       Date:  1989-04-15       Impact factor: 5.157
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  8 in total

1.  Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation.

Authors:  Liaman K Mamedova; Ruibo Wang; Pedro Besada; Bruce T Liang; Kenneth A Jacobson
Journal:  Pharmacol Res       Date:  2008-08-30       Impact factor: 7.658

Review 2.  New insights on P2X purinoceptors.

Authors:  P P Humphrey; G Buell; I Kennedy; B S Khakh; A D Michel; A Surprenant; D J Trezise
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-12       Impact factor: 3.000

3.  Strain Promoted Click Chemistry of 2- or 8-Azidopurine and 5-Azidopyrimidine Nucleosides and 8-Azidoadenosine Triphosphate with Cyclooctynes. Application to Living Cell Fluorescent Imaging.

Authors:  Jessica Zayas; Marie Annoual; Jayanta Kumar Das; Quentin Felty; Walter G Gonzalez; Jaroslava Miksovska; Nima Sharifai; Akira Chiba; Stanislaw F Wnuk
Journal:  Bioconjug Chem       Date:  2015-07-02       Impact factor: 4.774

4.  Nucleotide P2Y1 receptor agonists are in vitro and in vivo prodrugs of A1/A3 adenosine receptor agonists: implications for roles of P2Y1 and A1/A3 receptors in physiology and pathology.

Authors:  Theodore E Liston; Sonja Hinz; Christa E Müller; Deborah M Holstein; Jay Wendling; Roger J Melton; Mary Campbell; William S Korinek; R Rama Suresh; Dane A Sethre-Hofstad; Zhan-Guo Gao; Dilip K Tosh; Kenneth A Jacobson; James D Lechleiter
Journal:  Purinergic Signal       Date:  2020-10-31       Impact factor: 3.765

5.  Structure Activity Relationships for Derivatives of Adenosine-5'-Triphosphate as Agonists at P(2) Purinoceptors: Heterogeneity Within P(2X) and P(2Y) Subtypes.

Authors:  Geoffrey Burnstock; Bilha Fischer; Charles H V Hoyle; Michel Maillard; Airat U Ziganshin; Antonia L Brizzolara; Amy von Isakovics; José L Boyer; T Kendall Harden; Kenneth A Jacobson
Journal:  Drug Dev Res       Date:  2004-10-05       Impact factor: 4.360

6.  Effects of ATP and UTP in pheochromocytoma PC12 cells: evidence for the presence of three P2 receptors, only one of which subserves stimulation of norepinephrine release.

Authors:  B Nikodijevic; Y Sei; Y Shin; J W Daly
Journal:  Cell Mol Neurobiol       Date:  1994-02       Impact factor: 5.046

7.  Activity of Novel Adenine Nucleotide Derivatives as Agonists and Antagonists at Recombinant Rat P2X Receptors.

Authors:  Sean G Brown; Brian F King; Yong-Chul Kim; Soo Yeon Jang; Geoffrey Burnstock; Kenneth A Jacobson
Journal:  Drug Dev Res       Date:  2000-06-12       Impact factor: 4.360

8.  Identification of potent, selective P2Y-purinoceptor agonists: structure-activity relationships for 2-thioether derivatives of adenosine 5'-triphosphate.

Authors:  B Fischer; J L Boyer; C H Hoyle; A U Ziganshin; A L Brizzolara; G E Knight; J Zimmet; G Burnstock; T K Harden; K A Jacobson
Journal:  J Med Chem       Date:  1993-11-26       Impact factor: 7.446
  8 in total

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