| Literature DB >> 25178982 |
Long Shen1, Efstathia K Kapsogeorgou2, Meixing Yu1, Lakshmanan Suresh3, Kishore Malyavantham3, Anthanasios G Tzioufas2, Julian L Ambrus4.
Abstract
Sjogren's syndrome (SS) has been associated with the expression of anti-Ro and anti-La antibodies. Anti-salivary gland protein 1 (SP1) antibodies have recently been identified in patients with SS. The current work involved a cross sectional study to determine whether anti-SP1 antibodies were identified in particular subgroups of patients with SS. The results of this study revealed that anti-SP1 antibodies were present in the sera of 52% of SS patients while anti-Ro/anti-La was present in 63% of patients. 19% of patients had anti-SP1 without anti-Ro/anti-La. Patients with SS and lymphoma expressed anti-Ro, anti-La and anti-SP1 together. In SS associated with RA, 50% had antibodies anti-SP1 while 40% had anti-Ro/anti-La. In conclusion, anti-SP1 antibodies are commonly seen in both primary and secondary SS and rarely in normal controls. Future studies are needed to determine the roles and timing of expression of anti-SP1 antibodies in Sjogren's syndrome.Entities:
Keywords: Anti-La;; Anti-Ro;; Anti-salivary gland protein 1 (SP1); Rheumatoid arthritis;; Sjogren's syndrome;
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Year: 2014 PMID： 25178982 DOI： 10.1016/j.clim.2014.08.009
Source DB: PubMed Journal: Clin Immunol ISSN： 1521-6616 Impact factor: 3.969