Vatinee Y Bunya1, Mina Massaro-Giordano1, Frederick B Vivino2, Maureen G Maguire1, Alan N Baer3, John A Gonzales4,4, Gui-Shuang Ying1. 1. Department of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. 2. Department of Rheumatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. 3. Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD. 4. Francis I. Proctor Foundation, University of California, San Francisco, CA.
Abstract
PURPOSE: To evaluate the prevalence of novel candidate autoantibodies associated with Sjögren syndrome (SS) and their ability to identify those with SS among participants with dry eye enrolled in the Sjögren's International Collaborative Clinical Alliance (SICCA) study at the University of Pennsylvania (Penn). METHODS: All participants previously underwent a full ocular and systemic evaluation for possible SS as part of the SICCA study. An enzyme-linked immunosorbent assay was used to detect IgG, IgA, and IgM autoantibodies to salivary protein 1 (SP-1), parotid secretory protein (PSP), and carbonic anhydrase 6 from previously banked baseline serum samples from SICCA study participants enrolled at Penn. The prevalence rate of each autoantibody, calculated by considering the presence of any isotype as antibody positive, was compared between participants with dry eye with SS (n = 81) or without SS (n = 129) using the Fisher exact test. RESULTS: The prevalence of SP-1 IgM autoantibodies was higher in those with SS compared with those without SS (14% vs. 5%; P = 0.03). Similarly, the prevalence of PSP IgA autoantibodies was higher in those with SS compared with non-SS dry eye participants (21% vs. 11%; P = 0.048). There was no statistically significant difference in the prevalence of carbonic anhydrase 6 autoantibodies between those with or without SS (15% vs. 20%; P = 0.36). CONCLUSIONS: In the Penn SICCA cohort, SP-1 IgM and PSP IgA autoantibodies were more prevalent in the serum of SS-related dry eye participants compared with those without SS. Further longitudinal studies are needed to determine the clinical significance of these findings.
PURPOSE: To evaluate the prevalence of novel candidate autoantibodies associated with Sjögren syndrome (SS) and their ability to identify those with SS among participants with dry eye enrolled in the Sjögren's International Collaborative Clinical Alliance (SICCA) study at the University of Pennsylvania (Penn). METHODS: All participants previously underwent a full ocular and systemic evaluation for possible SS as part of the SICCA study. An enzyme-linked immunosorbent assay was used to detect IgG, IgA, and IgM autoantibodies to salivary protein 1 (SP-1), parotid secretory protein (PSP), and carbonic anhydrase 6 from previously banked baseline serum samples from SICCA study participants enrolled at Penn. The prevalence rate of each autoantibody, calculated by considering the presence of any isotype as antibody positive, was compared between participants with dry eye with SS (n = 81) or without SS (n = 129) using the Fisher exact test. RESULTS: The prevalence of SP-1 IgM autoantibodies was higher in those with SS compared with those without SS (14% vs. 5%; P = 0.03). Similarly, the prevalence of PSP IgA autoantibodies was higher in those with SS compared with non-SS dry eyeparticipants (21% vs. 11%; P = 0.048). There was no statistically significant difference in the prevalence of carbonic anhydrase 6 autoantibodies between those with or without SS (15% vs. 20%; P = 0.36). CONCLUSIONS: In the Penn SICCA cohort, SP-1 IgM and PSP IgA autoantibodies were more prevalent in the serum of SS-related dry eyeparticipants compared with those without SS. Further longitudinal studies are needed to determine the clinical significance of these findings.
Authors: A A Kruize; O P van Bijsterveld; R J Hené; P C de Wilde; T E Feltkamp; L Kater; J W Bijlsma Journal: Br J Ophthalmol Date: 1997-06 Impact factor: 4.638
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Authors: Troy E Daniels; Lindsey A Criswell; Caroline Shiboski; Stephen Shiboski; Hector Lanfranchi; Yi Dong; Morten Schiødt; Hisanori Umehara; Susumu Sugai; Stephen Challacombe; John S Greenspan Journal: Arthritis Rheum Date: 2009-05-15
Authors: P M Meiners; A Vissink; F G M Kroese; F K L Spijkervet; N Sillevis Smitt-Kamminga; W H Abdulahad; J Bulthuis-Kuiper; E Brouwer; S Arends; H Bootsma Journal: Ann Rheum Dis Date: 2014-01-28 Impact factor: 19.103