Literature DB >> 25177572

Acute myeloid leukemia presenting as "bowel upset": a case report.

Smeeta Gajendra1, Ajay Gogia2, Prasenjit Das3, Ritu Gupta4, Pranay Tanwar5.   

Abstract

Myeloid sarcomas (MS) are the extramedullary presentation of acute myeloid leukemias. At times, they are difficult to diagnose due to lack of any supportive findings in peripheral blood/bone marrow aspirate examination. The involvement of gastrointestinal tract (GIT) by myeloid sarcoma is rare phenomenon. This diagnostic challenge becomes more complex when it is added by vague clinical symptoms. Many times, they have been misdiagnosed as Non-Hodgkin's lymphoma, small round cell tumour or carcinoma. Here, we are reporting a case of myeloid sarcoma with no haematological abnormality which presented with the symptoms of bowel obstruction and a rare combination of inv. (16) and trisomy 22. The journey to reach the conclusive diagnosis in this case is interesting and sensitizes us to have high index of suspicion in a case, where there is paucity of clinical evidences.

Entities:  

Keywords:  Acute myeloid leukemia; Blast; Intussusception; Lymphadenopathy; Myeloid sarcomas

Year:  2014        PMID: 25177572      PMCID: PMC4149078          DOI: 10.7860/JCDR/2014/9112.4578

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  10 in total

1.  Isolated granulocytic sarcoma followed by acute myelogenous leukemia type FAB-M2 associated with inversion 16 and trisomies 9 and 22.

Authors:  F Morel; A Herry; M-J Le Bris; G Le Calvez; V Marion; C Berthou; M De Braekeleer
Journal:  Leukemia       Date:  2002-12       Impact factor: 11.528

2.  Myeloid sarcoma of the nasopharynx mimicking an aggressive lymphoma.

Authors:  Jacques Raphael; Alexander Valent; Colette Hanna; Nathalie Auger; Odile Casiraghi; Vincent Ribrag; Stephane De Botton; Veronique Saada
Journal:  Head Neck Pathol       Date:  2013-10-08

Review 3.  Granulocytic sarcoma of the small intestine.

Authors:  Shane K Kohl; Patricia Aoun
Journal:  Arch Pathol Lab Med       Date:  2006-10       Impact factor: 5.534

4.  Association of an inversion of chromosome 16 with abnormal marrow eosinophils in acute myelomonocytic leukemia. A unique cytogenetic-clinicopathological association.

Authors:  M M Le Beau; R A Larson; M A Bitter; J W Vardiman; H M Golomb; J D Rowley
Journal:  N Engl J Med       Date:  1983-09-15       Impact factor: 91.245

Review 5.  Clinico-pathological characteristics of myeloid sarcoma at diagnosis and during follow-up: report of 12 cases from a single institution.

Authors:  Massimo Breccia; Franco Mandelli; Maria C Petti; Mariella D'Andrea; Edoardo Pescarmona; Stefano A Pileri; Ida Carmosino; Eleonora Russo; Paolo De Fabritiis; Giuliana Alimena
Journal:  Leuk Res       Date:  2004-11       Impact factor: 3.156

6.  Granulocytic sarcoma of the small intestine preceding acute myelomonocytic leukemia with abnormal eosinophils and inv(16).

Authors:  S J Russell; F J Giles; D S Thompson; D J Scanlon; H Walker; J D Richards
Journal:  Cancer Genet Cytogenet       Date:  1988-10-15

7.  Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia.

Authors:  Apostolia-Maria Tsimberidou; Hagop M Kantarjian; Sijin Wen; Michael J Keating; Susan O'Brien; Mark Brandt; Sherry Pierce; Emil J Freireich; L Jeffrey Medeiros; Elihu Estey
Journal:  Cancer       Date:  2008-09-15       Impact factor: 6.860

8.  [An unusual way of manifesting acute granulocytic leukemia: granulocytic sarcoma of the breast. Apropos of a case with trisomy 22].

Authors:  F Turpin; M Trassard; A Bourguignat; J L Floiras; V Le Doussal; P Eydoux
Journal:  Nouv Rev Fr Hematol       Date:  1986

9.  Granulocytic sarcoma of bowel: CT findings.

Authors:  Eugene K Choi; Hyun Kwon Ha; Seong Ho Park; Soon Jin Lee; Seung Eun Jung; Kyoung Won Kim; Seung Soo Lee
Journal:  Radiology       Date:  2007-04-19       Impact factor: 11.105

10.  Granulocytic sarcoma of the small bowel, greater omentum and peritoneum associated with a CBFβ/MYH11 fusion and inv(16) (p13q22): a case report.

Authors:  Paloma Alvarez; Carmen A Navascués; Carlos Ordieres; María Pipa; Iván F Vega; Pablo Granero; José A Alvarez; Manuel Rodríguez
Journal:  Int Arch Med       Date:  2011-01-21
  10 in total
  6 in total

1.  Myeloid sarcoma of the small intestine in a patient without overt acute myeloid leukaemia: a challenging diagnosis of a rare condition.

Authors:  Rodrigo Athayde Nemésio; Beatriz Costa; Carlos Abrantes; Júlio Soares Leite
Journal:  BMJ Case Rep       Date:  2018-05-30

Review 2.  Intussusception: a rare complication in a patient with acute leukaemia after consolidation chemotherapy.

Authors:  Ayman Qasrawi; Mouhanna Abu Ghanimeh; Omar Abughanimeh; Abdulraheem Qasem
Journal:  BMJ Case Rep       Date:  2017-02-28

3.  Ileocolic Intussusception in a Leukemic Adult Patient: A Case Report and Review of the Literature.

Authors:  Ayoub Innabi; Wa'el Tuqan; Alia Alawneh; Alaa Saleh; Kamal Alrabi; Lina Marei
Journal:  Case Rep Surg       Date:  2016-10-20

4.  Isolated Enteric Myeloid Sarcoma as a Rare Etiology of Small Bowel Obstruction in a Young Female Patient.

Authors:  Nagwa Abou-Ghanem; Eltaib Saad; Ira A Oliff; Adi Gidron; Dorota Filipiuk
Journal:  Gastroenterology Res       Date:  2022-01-10

5.  Acute Myelogenous Leukemia as a Rare Cause of Duodenal Ulcers.

Authors:  Lindsay A Sobotka; Tessa Crilley; Edward Levine; Anita Afzali
Journal:  ACG Case Rep J       Date:  2019-08-01

6.  Isolated myeloid sarcoma presenting with small bowel obstruction: a case report.

Authors:  Rie Mizumoto; Masanori Tsujie; Tomoko Wakasa; Kotaro Kitani; Hironobu Manabe; Shuichi Fukuda; Kaoru Okada; Shumpei Satoi; Hajime Ishikawa; Toshihiko Kawasaki; Hitoshi Hanamoto; Masao Yukawa; Masatoshi Inoue
Journal:  Surg Case Rep       Date:  2020-01-03
  6 in total

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