Thomas Aparicio1, Olivier Schischmanoff2, Cecile Poupardin3, Florence Mary4, Nadem Soufir5, Christophe Barrat6, Guy Bellaiche7, Marouane Boubaya8, Laurence Choudat9, Joel Cucherousset10, Gaetan DesGuetz11, Philippe Wind12, Robert Benamouzig4. 1. Gastroenterology, Avicenne Hospital, APHP, HUPSSD, Sorbonne-Paris Cité, University Paris 13, Bobigny, France. Electronic address: thomas.aparicio@avc.aphp.fr. 2. Biochemistry, Avicenne Hospital, APHP, HUPSSD, Sorbonne-Paris Cité, University Paris 13, Bobigny, France. 3. Gastroenterology, Montfermeil Hospital, Montfermeil, France. 4. Gastroenterology, Avicenne Hospital, APHP, HUPSSD, Sorbonne-Paris Cité, University Paris 13, Bobigny, France. 5. Biochemistry, Bichat Hospital, Sorbonne-Paris Cité, University Paris 7, Paris, France. 6. Surgery, Jean Verdier Hospital, APHP, HUPSSD, Sorbonne-Paris Cité, University Paris 13, Bondy, France. 7. Gastroenterology, Robert Ballanger Hospital, Aulnay, France. 8. Research Unit, Avicenne Hospital, APHP, HUPSSD, Sorbonne-Paris Cité, Université Paris 13, Bobigny, France. 9. Anatomopathology, Bichat Hospital, Sorbonne-Paris Cité, University Paris 7, Paris, France. 10. Anatomopathology, Montfermeil Hospital, Montfermeil, France. 11. Oncology, Avicenne Hospital, APHP, HUPSSD, Sorbonne-Paris Cité, University Paris 13, Bobigny, France. 12. Surgery, Avicenne Hospital, APHP, HUPSSD, Sorbonne-Paris Cité, University Paris 13, Bobigny, France.
Abstract
AIMS: Colorectal cancer (CRC) occurs mostly in the elderly. However, the biology of CRC in elderly has been poorly studied. This study examined the prevalence of deficient mismatch repair phenotype (dMMR) and BRAF mutations according to age. PATIENTS AND METHODS: MMR phenotype was prospectively determined by molecular analysis in patients of all ages undergoing surgery for CRC. BRAF V600E mutation status was analysed in a subset of dMMR tumours. RESULTS: A total of 754 patients who underwent surgery between 2005 and 2008 were included in the study. Amongst them, 272 (36%) were ≥75years old. The proportion of women <75 was 38% and that ≥75 was 53% (p<0.0001). The prevalence of dMMR was 19.4% in patients ≥75 and 10.7% in patients <75 (p=0.0017). For patients ≥75, the prevalence of dMMR was significantly higher in women than in men (27% vs 10.2%, respectively; p=0.003) but was similar in women and men <75 (12.5% vs 9.7%, respectively; p=0.4). We examined BRAF mutation status in 80 patients with dMMR tumours. The V600E BRAF mutation was significantly more frequent in patients ≥75 than in patients <75 (72.2% vs 11.4%, respectively; p<0.001). In patients ≥75, there was no difference in the prevalence of the BRAF V600E mutation according to sex (78% in women and 70% in men, p=0.9). CONCLUSIONS: The prevalence of dMMR in CRC is high in patients over 75. In elderly patients, dMMR tumours are significantly more frequent in women than in men. The BRAF mutation is frequent in elderly patients with CRC.
AIMS: Colorectal cancer (CRC) occurs mostly in the elderly. However, the biology of CRC in elderly has been poorly studied. This study examined the prevalence of deficient mismatch repair phenotype (dMMR) and BRAF mutations according to age. PATIENTS AND METHODS: MMR phenotype was prospectively determined by molecular analysis in patients of all ages undergoing surgery for CRC. BRAFV600E mutation status was analysed in a subset of dMMRtumours. RESULTS: A total of 754 patients who underwent surgery between 2005 and 2008 were included in the study. Amongst them, 272 (36%) were ≥75years old. The proportion of women <75 was 38% and that ≥75 was 53% (p<0.0001). The prevalence of dMMR was 19.4% in patients ≥75 and 10.7% in patients <75 (p=0.0017). For patients ≥75, the prevalence of dMMR was significantly higher in women than in men (27% vs 10.2%, respectively; p=0.003) but was similar in women and men <75 (12.5% vs 9.7%, respectively; p=0.4). We examined BRAF mutation status in 80 patients with dMMRtumours. The V600EBRAF mutation was significantly more frequent in patients ≥75 than in patients <75 (72.2% vs 11.4%, respectively; p<0.001). In patients ≥75, there was no difference in the prevalence of the BRAFV600E mutation according to sex (78% in women and 70% in men, p=0.9). CONCLUSIONS: The prevalence of dMMR in CRC is high in patients over 75. In elderly patients, dMMRtumours are significantly more frequent in women than in men. The BRAF mutation is frequent in elderly patients with CRC.
Authors: George Kunnackal John; Vipin Das Villgran; Christine Caufield-Noll; Francis M Giardiello Journal: Fam Cancer Date: 2021-01-11 Impact factor: 2.375
Authors: Andreas Sperlich; Alexander Balmert; Dietrich Doll; Sabine Bauer; Fabian Franke; Gisela Keller; Dirk Wilhelm; Anna Mur; Michael Respondek; Helmut Friess; Ulrich Nitsche; Klaus-Peter Janssen Journal: BMC Cancer Date: 2018-10-19 Impact factor: 4.430
Authors: George Kunnackal John; Vipin Das Villgran; Christine Caufield-Noll; Francis Giardiello Journal: Fam Cancer Date: 2020-09-11 Impact factor: 2.375
Authors: John J McNeil; Peter Gibbs; Suzanne G Orchard; Jessica E Lockery; Wendy B Bernstein; Yin Cao; Leslie Ford; Andrew Haydon; Brenda Kirpach; Finlay Macrae; Catriona McLean; Jeremy Millar; Anne M Murray; Mark R Nelson; Galina Polekhina; Christopher M Reid; Ellen Richmond; Luz Maria Rodríguez; Raj C Shah; Jeanne Tie; Asad Umar; G J van Londen; Kathlyn Ronaldson; Rory Wolfe; Robyn L Woods; John Zalcberg; Andrew T Chan Journal: J Natl Cancer Inst Date: 2021-03-01 Impact factor: 13.506