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Literature DB >> 25174818

Hi-TEC reprogramming for organ regeneration.

Abstract

The induction of cell reprogramming by transcription factors into alternative cell fates opens new avenues for regenerative medicine. Thymic epithelial cells that were obtained from fibroblasts by Foxn1 overexpression support the formation of an ectopic thymus following transplantation.

Entities: Gene

Mesh：

Substances：

Year: 2014 PMID： 25174818 DOI： 10.1038/ncb3032

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

13 in total

1. Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells.

Authors: Paola Bonfanti; Stéphanie Claudinot; Alessandro W Amici; Alison Farley; C Clare Blackburn; Yann Barrandon
Journal: Nature Date: 2010-08-19 Impact factor: 49.962

2. Formation of a functional thymus initiated by a postnatal epithelial progenitor cell.

Authors: Conrad C Bleul; Tatiana Corbeaux; Alexander Reuter; Paul Fisch; Jürgen Schulte Mönting; Thomas Boehm
Journal: Nature Date: 2006-06-22 Impact factor: 49.962

3. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.

Authors: Toshiro Sato; Johan H van Es; Hugo J Snippert; Daniel E Stange; Robert G Vries; Maaike van den Born; Nick Barker; Noah F Shroyer; Marc van de Wetering; Hans Clevers
Journal: Nature Date: 2010-11-28 Impact factor: 49.962

4. New member of the winged-helix protein family disrupted in mouse and rat nude mutations.

Authors: M Nehls; D Pfeifer; M Schorpp; H Hedrich; T Boehm
Journal: Nature Date: 1994-11-03 Impact factor: 49.962

Review 5. Rejuvenation of the aging T cell compartment.

Authors: Amanda M Holland; Marcel R M van den Brink
Journal: Curr Opin Immunol Date: 2009-07-14 Impact factor: 7.486

6. Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development.

Authors: Audrey V Parent; Holger A Russ; Imran S Khan; Taylor N LaFlam; Todd C Metzger; Mark S Anderson; Matthias Hebrok
Journal: Cell Stem Cell Date: 2013-05-16 Impact factor: 24.633

7. Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo.

Authors: Xiaoning Sun; Jun Xu; Hongxia Lu; Wang Liu; Zhenchuan Miao; Xin Sui; Haisong Liu; Li Su; Weichao Du; Qihua He; Fangyuan Chen; Yan Shi; Hongkui Deng
Journal: Cell Stem Cell Date: 2013-08-01 Impact factor: 24.633

Hi-TEC reprogramming for organ regeneration.

1. Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells.

2. Formation of a functional thymus initiated by a postnatal epithelial progenitor cell.

3. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.

4. New member of the winged-helix protein family disrupted in mouse and rat nude mutations.

Review 5. Rejuvenation of the aging T cell compartment.

6. Generation of functional thymic epithelium from human embryonic stem cells that supports host T cell development.

7. Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo.

8. Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium.

9. Regeneration of the aged thymus by a single transcription factor.

10. An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts.

1. Construction of Thymus Organoids from Decellularized Thymus Scaffolds.