OBJECTIVE: Myxofibrosarcoma (MFS) is characterized by a high frequency of local recurrence after surgery because of infiltrative growth of the tumor cells. This infiltrative growth creates a characteristic 'tail-like' pattern on magnetic resonance imaging (MRI), and it has been reported that this pattern is especially obvious on gadolinium-enhanced MRI (Gd MRI). However, the relationship between the tail-like pattern seen on Gd MRI and clinicopathological features of MFS is still not clear. In this study, we performed a retrospective analysis to identify clinicopathological factors related to the tail-like pattern of the MRI findings in patients with MFS. MATERIALS AND METHODS: We retrospectively analyzed 50 patients with MFS to identify factors related to the tail-like pattern. RESULTS: On Gd MRI, 32 of the 50 patients presented the tail-like pattern, whereas 18 presented a solid pattern. The clincopathological factors related to the tail-like pattern were evaluated by chi-squared test. A superficial origin (p = 0.0009) was most significantly related to the tail-like pattern. The 5-year recurrence-free survival (RFS) rate was 75.6 % for patients showing the tail-like pattern and 90.9 % for those showing the solid pattern. The corresponding 5-year disease-free survival (DFS) rates were 64.7 and 79.3 %, respectively. Thus in terms of both 5-year RFS and DFS, patients with the tail-like pattern tended to have a poorer outcome. CONCLUSION: A superficial origin of MFS is significantly related to a tail-like pattern on Gd MRI. The tail-like pattern is associated with poorer prognosis. Further studies of tumor depth and the tail-like pattern on Gd MRI are needed.
OBJECTIVE: Myxofibrosarcoma (MFS) is characterized by a high frequency of local recurrence after surgery because of infiltrative growth of the tumor cells. This infiltrative growth creates a characteristic 'tail-like' pattern on magnetic resonance imaging (MRI), and it has been reported that this pattern is especially obvious on gadolinium-enhanced MRI (Gd MRI). However, the relationship between the tail-like pattern seen on Gd MRI and clinicopathological features of MFS is still not clear. In this study, we performed a retrospective analysis to identify clinicopathological factors related to the tail-like pattern of the MRI findings in patients with MFS. MATERIALS AND METHODS: We retrospectively analyzed 50 patients with MFS to identify factors related to the tail-like pattern. RESULTS: On Gd MRI, 32 of the 50 patients presented the tail-like pattern, whereas 18 presented a solid pattern. The clincopathological factors related to the tail-like pattern were evaluated by chi-squared test. A superficial origin (p = 0.0009) was most significantly related to the tail-like pattern. The 5-year recurrence-free survival (RFS) rate was 75.6 % for patients showing the tail-like pattern and 90.9 % for those showing the solid pattern. The corresponding 5-year disease-free survival (DFS) rates were 64.7 and 79.3 %, respectively. Thus in terms of both 5-year RFS and DFS, patients with the tail-like pattern tended to have a poorer outcome. CONCLUSION: A superficial origin of MFS is significantly related to a tail-like pattern on Gd MRI. The tail-like pattern is associated with poorer prognosis. Further studies of tumor depth and the tail-like pattern on Gd MRI are needed.
Authors: Mark W Manoso; Jeffrey Pratt; John H Healey; Patrick J Boland; Edward A Athanasian Journal: Clin Orthop Relat Res Date: 2006-09 Impact factor: 4.176
Authors: Brendan Waters; David M Panicek; Robert A Lefkowitz; Cristina R Antonescu; John H Healey; Edward A Athanasian; Murray F Brennan Journal: AJR Am J Roentgenol Date: 2007-02 Impact factor: 3.959
Authors: J M Coindre; P Terrier; L Guillou; V Le Doussal; F Collin; D Ranchère; X Sastre; M O Vilain; F Bonichon; B N'Guyen Bui Journal: Cancer Date: 2001-05-15 Impact factor: 6.860
Authors: Robert A Lefkowitz; Jonathan Landa; Sinchun Hwang; Emily C Zabor; Chaya S Moskowitz; Narasimhan P Agaram; David M Panicek Journal: Skeletal Radiol Date: 2013-01-15 Impact factor: 2.199
Authors: Eric A Walker; Jonelle M Petscavage; Pamela L Brian; Chika Iloanusi Logie; Kenneth M Montini; Mark D Murphey Journal: Sarcoma Date: 2012-06-28