| Literature DB >> 25170159 |
Maanasa Raghavan1, Michael DeGiorgio2, Anders Albrechtsen3, Ida Moltke4, Pontus Skoglund5, Thorfinn S Korneliussen1, Bjarne Grønnow6, Martin Appelt6, Hans Christian Gulløv6, T Max Friesen7, William Fitzhugh8, Helena Malmström9, Simon Rasmussen10, Jesper Olsen11, Linea Melchior12, Benjamin T Fuller13, Simon M Fahrni13, Thomas Stafford14, Vaughan Grimes15, M A Priscilla Renouf16, Jerome Cybulski17, Niels Lynnerup12, Marta Mirazon Lahr18, Kate Britton19, Rick Knecht20, Jette Arneborg21, Mait Metspalu22, Omar E Cornejo23, Anna-Sapfo Malaspinas1, Yong Wang24, Morten Rasmussen1, Vibha Raghavan25, Thomas V O Hansen26, Elza Khusnutdinova27, Tracey Pierre1, Kirill Dneprovsky28, Claus Andreasen29, Hans Lange29, M Geoffrey Hayes30, Joan Coltrain31, Victor A Spitsyn32, Anders Götherström33, Ludovic Orlando1, Toomas Kivisild34, Richard Villems22, Michael H Crawford35, Finn C Nielsen26, Jørgen Dissing12, Jan Heinemeier11, Morten Meldgaard1, Carlos Bustamante36, Dennis H O'Rourke31, Mattias Jakobsson37, M Thomas P Gilbert1, Rasmus Nielsen38, Eske Willerslev39.
Abstract
The New World Arctic, the last region of the Americas to be populated by humans, has a relatively well-researched archaeology, but an understanding of its genetic history is lacking. We present genome-wide sequence data from ancient and present-day humans from Greenland, Arctic Canada, Alaska, Aleutian Islands, and Siberia. We show that Paleo-Eskimos (~3000 BCE to 1300 CE) represent a migration pulse into the Americas independent of both Native American and Inuit expansions. Furthermore, the genetic continuity characterizing the Paleo-Eskimo period was interrupted by the arrival of a new population, representing the ancestors of present-day Inuit, with evidence of past gene flow between these lineages. Despite periodic abandonment of major Arctic regions, a single Paleo-Eskimo metapopulation likely survived in near-isolation for more than 4000 years, only to vanish around 700 years ago.Entities:
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Year: 2014 PMID： 25170159 DOI： 10.1126/science.1255832
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728