N-Acetyltransferase polymorphism and human cancer risk.

Because of the important role ofN-acetyltransferase (NAT) enzymes in both metabolic activation and detoxification of certain precarcinogens, such as homo-and heterocyclic arylamines, extensive research in the past has focused on the relationship between the distribution of different variants of these enzymes and cancer susceptibility. In this context, we examined the relationship between the acetylator type of two NAT isozymes (NAT1 and NAT2) and cancer risk. It was shown that any independent overall association of those diseases with acetylation for eitherNATl orNAT2 is likely to be weak at most. Besides individual genetic profile, differences in the degree of exposure to environmental precarcinogens should also be considered. It was suggested that smoking and red meat intake were associated with bothNATl andNAT2 genotype in the carcinogenesis. A gene-gene interaction, even linkage betweenNATl andNAT2 may also exist.