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Literature DB >> 25167470

The first synthesis of the antiangiogenic homoisoflavanone, cremastranone.

Bit Lee¹, Halesha D Basavarajappa, Rania S Sulaiman, Xiang Fei, Seung-Yong Seo, Timothy W Corson.

Abstract

An antiangiogenic homoisoflavanone, cremastranone, was synthesized for the first time. This scalable synthesis, which includes selective demethylation, could be used to develop lead molecules to treat angiogenesis-induced eye diseases. Synthetic cremastranone inhibited the proliferation, migration and tube formation ability of human retinal microvascular endothelial cells, important steps in pathological angiogenesis.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2014 PMID： 25167470 PMCID： PMC4167916 DOI： 10.1039/c4ob01604a

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

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5. Homoisoflavanone inhibits retinal neovascularization through cell cycle arrest with decrease of cdc2 expression.

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Authors: J S Penn; A Madan; R B Caldwell; M Bartoli; R W Caldwell; M E Hartnett
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10. Inhibition of choroidal neovascularization by homoisoflavanone, a new angiogenesis inhibitor.

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5. Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids.

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