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Literature DB >> 14994197

Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata.

Joong Sup Shim¹, Jin Hee Kim, Jiyong Lee, Si Na Kim, Ho Jeong Kwon.

Abstract

A homoisoflavanone, 5,7-dihydroxy-3-(3-hydroxy-4-methoxybenzyl)-6-methoxychroman-4-one ( 1), was isolated from the bulb of Cremastra appendiculata (D. Don) Makino (Orchidaceae) as a potent inhibitor of angiogenesis. It inhibited basic fibroblast growth factor (bFGF)-induced in vitro angiogenesis and in vivo angiogenesis of the chorioallantoic membrane (CAM) of chick embryo without showing any toxicity.

Entities: Chemical Disease Gene Species

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Year: 2004 PMID： 14994197 DOI： 10.1055/s-2004-815496

Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352

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Cited

17 in total

1. Synthesis and Biological Evaluation of Novel Homoisoflavonoids for Retinal Neovascularization.

Authors: Halesha D Basavarajappa; Bit Lee; Seung-Yong Seo; Timothy W Corson; Hyungjun Lee; Rania S Sulaiman; Hongchan An; Carlos Magaña; Mehdi Shadmand; Alexandra Vayl; Gangaraju Rajashekhar; Eun-Yeong Kim; Young-Ger Suh; Kiho Lee
Journal: J Med Chem Date: 2015-06-16 Impact factor: 7.446

2. Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids.

Authors: Bit Lee; Wei Sun; Hyungjun Lee; Halesha Basavarajappa; Rania S Sulaiman; Kamakshi Sishtla; Xiang Fei; Timothy W Corson; Seung-Yong Seo
Journal: Bioorg Med Chem Lett Date: 2016-07-21 Impact factor: 2.823

3. The Antiangiogenic Activity of Naturally Occurring and Synthetic Homoisoflavonoids from the Hyacinthaceae ( sensu APGII).

Authors: Sianne Schwikkard; Hannah Whitmore; Kamakshi Sishtla; Rania S Sulaiman; Trupti Shetty; Halesha D Basavarajappa; Catherine Waller; Alaa Alqahtani; Lennart Frankemoelle; Andy Chapman; Neil Crouch; Wolfgang Wetschnig; Walter Knirsch; Jacky Andriantiana; Eduard Mas-Claret; Moses K Langat; Dulcie Mulholland; Timothy W Corson
Journal: J Nat Prod Date: 2019-04-05 Impact factor: 4.050

4. Efficacy of early treatment on 52 patients with preneoplastic hepatitis B virus-associated hepatocellular carcinoma by compound Phyllanthus Urinaria L.

Authors: Guang-dong Tong; Xi Zhang; Da-qiao Zhou; Chun-shan Wei; Jin-song He; Chun-ling Xiao; Xin-liang Liu; Ying-jun Zheng; Si-nuan Chen; Hai-hong Tang
Journal: Chin J Integr Med Date: 2013-03-25 Impact factor: 1.978

5. The first synthesis of the antiangiogenic homoisoflavanone, cremastranone.

Authors: Bit Lee; Halesha D Basavarajappa; Rania S Sulaiman; Xiang Fei; Seung-Yong Seo; Timothy W Corson
Journal: Org Biomol Chem Date: 2014-08-28 Impact factor: 3.876

6. Enantioselective Synthesis of Homoisoflavanones by Asymmetric Transfer Hydrogenation and Their Biological Evaluation for Antiangiogenic Activity.

Authors: Myunghoe Heo; Bit Lee; Kamakshi Sishtla; Xiang Fei; Sanha Lee; Soojun Park; Yue Yuan; Seul Lee; Sangil Kwon; Jungeun Lee; Sanghee Kim; Timothy W Corson; Seung-Yong Seo
Journal: J Org Chem Date: 2019-08-05 Impact factor: 4.354

Anti-angiogenic activity of a homoisoflavanone from Cremastra appendiculata.

1. Synthesis and Biological Evaluation of Novel Homoisoflavonoids for Retinal Neovascularization.

2. Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids.

3. The Antiangiogenic Activity of Naturally Occurring and Synthetic Homoisoflavonoids from the Hyacinthaceae ( sensu APGII).

4. Efficacy of early treatment on 52 patients with preneoplastic hepatitis B virus-associated hepatocellular carcinoma by compound Phyllanthus Urinaria L.

5. The first synthesis of the antiangiogenic homoisoflavanone, cremastranone.

6. Enantioselective Synthesis of Homoisoflavanones by Asymmetric Transfer Hydrogenation and Their Biological Evaluation for Antiangiogenic Activity.

Review 7. Natural product inhibitors of ocular angiogenesis.

8. Synthesis and mechanistic studies of a novel homoisoflavanone inhibitor of endothelial cell growth.

9. Inhibition of choroidal neovascularization by homoisoflavanone, a new angiogenesis inhibitor.

10. A novel small molecule ameliorates ocular neovascularisation and synergises with anti-VEGF therapy.