Literature DB >> 25165411

Small-Molecule End-Groups of Linear Polymer Determine Cell-type Gene-Delivery Efficacy.

Joel Sunshine1, Jordan J Green1, Kerry P Mahon2, Fan Yang2, Ahmed A Eltoukhy2, David N Nguyen2, Robert Langer2, Daniel G Anderson2.   

Abstract

End-modified polymers are promising for the nonviral delivery of genes to cancer cells, immune cells, and human stem cells and point to polymer end-groups as regulators for cell-type specificity. A library of polymers has been synthesized and, although some polymers are strong transfection agents overall, for each cell type, a particular polymer is most effective.
Copyright © 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Cell targeting; Gene delivery; Nanoparticles; Polymer library; Transfection

Year:  2009        PMID： 25165411      PMCID： PMC4143259          DOI： 10.1002/adma.200901718

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  22 in total

1.  Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery.

Authors:  Daniel G Anderson; David M Lynn; Robert Langer
Journal:  Angew Chem Int Ed Engl       Date:  2003-07-14       Impact factor: 15.336

2.  Structure/property studies of polymeric gene delivery using a library of poly(beta-amino esters).

Authors:  Daniel G Anderson; Akin Akinc; Naushad Hossain; Robert Langer
Journal:  Mol Ther       Date:  2005-03       Impact factor: 11.454

3.  Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

Authors:  Z Shen; G Reznikoff; G Dranoff; K L Rock
Journal:  J Immunol       Date:  1997-03-15       Impact factor: 5.422

Review 4.  Polymers for gene delivery across length scales.

Authors:  David Putnam
Journal:  Nat Mater       Date:  2006-06       Impact factor: 43.841

5.  Rapid optimization of gene delivery by parallel end-modification of poly(beta-amino ester)s.

Authors:  Gregory T Zugates; Weidan Peng; Andreas Zumbuehl; Siddharth Jhunjhunwala; Yu-Hung Huang; Robert Langer; Janet A Sawicki; Daniel G Anderson
Journal:  Mol Ther       Date:  2007-03-20       Impact factor: 11.454

Review 6.  Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives.

Authors:  Michael Neu; Dagmar Fischer; Thomas Kissel
Journal:  J Gene Med       Date:  2005-08       Impact factor: 4.565

7.  A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy.

Authors:  S Moein Moghimi; Peter Symonds; J Clifford Murray; A Christy Hunter; Grazyna Debska; Adam Szewczyk
Journal:  Mol Ther       Date:  2005-06       Impact factor: 11.454

8.  Biodegradable polymeric vectors for gene delivery to human endothelial cells.

Authors:  Jordan J Green; Julie Shi; Eugene Chiu; Elizaveta S Leshchiner; Robert Langer; Daniel G Anderson
Journal:  Bioconjug Chem       Date:  2006 Sep-Oct       Impact factor: 4.774

9.  A polymer library approach to suicide gene therapy for cancer.

Authors:  Daniel G Anderson; Weidan Peng; Akin Akinc; Naushad Hossain; Anat Kohn; Robert Padera; Robert Langer; Janet A Sawicki
Journal:  Proc Natl Acad Sci U S A       Date:  2004-11-01       Impact factor: 11.205

10.  Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells.

Authors:  Shayna L Showalter; Yu-Hung Huang; Agneszka Witkiewicz; Christina L Costantino; Charles J Yeo; Jordan J Green; Robert Langer; Daniel G Anderson; Janet A Sawicki; Jonathan R Brody
Journal:  Cancer Biol Ther       Date:  2008-10-03       Impact factor: 4.742
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  50 in total

1.  A novel assay for quantifying the number of plasmids encapsulated by polymer nanoparticles.

Authors:  Nupura S Bhise; Ron B Shmueli; Jose Gonzalez; Jordan J Green
Journal:  Small       Date:  2011-12-05       Impact factor: 13.281

2.  Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours.

Authors:  Johan Karlsson; Yuan Rui; Kristen L Kozielski; Amanda L Placone; Olivia Choi; Stephany Y Tzeng; Jayoung Kim; Jamal J Keyes; Max I Bogorad; Kathleen Gabrielson; Hugo Guerrero-Cazares; Alfredo Quiñones-Hinojosa; Peter C Searson; Jordan J Green
Journal:  Nanoscale       Date:  2019-10-15       Impact factor: 7.790

3.  Scaffold-mediated BMP-2 minicircle DNA delivery accelerated bone repair in a mouse critical-size calvarial defect model.

Authors:  Michael Keeney; Michael T Chung; Elizabeth R Zielins; Kevin J Paik; Adrian McArdle; Shane D Morrison; Ryan C Ransom; Namrata Barbhaiya; David Atashroo; Gunilla Jacobson; Richard N Zare; Michael T Longaker; Derrick C Wan; Fan Yang
Journal:  J Biomed Mater Res A       Date:  2016-06-03       Impact factor: 4.396

4.  Programming stem cells for therapeutic angiogenesis using biodegradable polymeric nanoparticles.

Authors:  Michael Keeney; Lorenzo Deveza; Fan Yang
Journal:  J Vis Exp       Date:  2013-09-27       Impact factor: 1.355

5.  The relationship between terminal functionalization and molecular weight of a gene delivery polymer and transfection efficacy in mammary epithelial 2-D cultures and 3-D organotypic cultures.

Authors:  Nupura S Bhise; Ryan S Gray; Joel C Sunshine; Soe Htet; Andrew J Ewald; Jordan J Green
Journal:  Biomaterials       Date:  2010-07-31       Impact factor: 12.479

6.  Uptake and transfection with polymeric nanoparticles are dependent on polymer end-group structure, but largely independent of nanoparticle physical and chemical properties.

Authors:  Joel C Sunshine; Daniel Y Peng; Jordan J Green
Journal:  Mol Pharm       Date:  2012-09-27       Impact factor: 4.939

7.  Cystamine-terminated poly(beta-amino ester)s for siRNA delivery to human mesenchymal stem cells and enhancement of osteogenic differentiation.

Authors:  Stephany Y Tzeng; Ben P Hung; Warren L Grayson; Jordan J Green
Journal:  Biomaterials       Date:  2012-08-04       Impact factor: 12.479

8.  Non-virally engineered human adipose mesenchymal stem cells produce BMP4, target brain tumors, and extend survival.

Authors:  Antonella Mangraviti; Stephany Y Tzeng; David Gullotti; Kristen L Kozielski; Jennifer E Kim; Michael Seng; Sara Abbadi; Paula Schiapparelli; Rachel Sarabia-Estrada; Angelo Vescovi; Henry Brem; Alessandro Olivi; Betty Tyler; Jordan J Green; Alfredo Quinones-Hinojosa
Journal:  Biomaterials       Date:  2016-05-21       Impact factor: 12.479

9.  Differential polymer structure tunes mechanism of cellular uptake and transfection routes of poly(β-amino ester) polyplexes in human breast cancer cells.

Authors:  Jayoung Kim; Joel C Sunshine; Jordan J Green
Journal:  Bioconjug Chem       Date:  2013-12-20       Impact factor: 4.774

10.  Evaluation of polymeric gene delivery nanoparticles by nanoparticle tracking analysis and high-throughput flow cytometry.

Authors:  Ron B Shmueli; Nupura S Bhise; Jordan J Green
Journal:  J Vis Exp       Date:  2013-03-01       Impact factor: 1.355
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