Direct arylation of C(sp3)-H bonds in aliphatic amides with diaryliodonium salts in the presence of a nickel catalyst.

The Ni(II)-catalyzed direct arylation of C(sp(3))-H (methyl and methylene) bonds in aliphatic amides containing an 8-aminoquinoline moiety as the directing group with diaryliodonium salts as coupling electrophiles is described. A wide variety of functional groups are tolerated in the reaction. The reaction represents the first example of the Ni-catalyzed direct arylation of C(sp(3))-H bonds with diaryliodonium salts.