| Literature DB >> 25159595 |
Temitope O Olomola1, Salerwe Mosebi2, Rosalyn Klein1, Telisha Traut-Johnstone2, Judy Coates2, Raymond Hewer2, Perry T Kaye3.
Abstract
A series of seven novel, rationally designed N-substituted 3-{3,5-dimethylfuro[3,2-g]coumarin-6-yl}propanamides have been prepared as potential HIV-1 integrase (IN) inhibitors via a five-step pathway commencing with resorcinol and diethyl 2-acetylglutarate, and the HIV-1 IN inhibition potential of these compounds has been examined relative to raltegravir, a known HIV-1 IN inhibitor.Entities:
Keywords: Furocoumarins; HIV-1 integrase; Rational design; Strand-transfer inhibitors
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Year: 2014 PMID： 25159595 DOI： 10.1016/j.bioorg.2014.07.008
Source DB: PubMed Journal: Bioorg Chem ISSN： 0045-2068 Impact factor: 5.275