Khaled Z Abd-Elmoniem1, Aylin B Unsal2, Sarah Eshera1, Jatin R Matta1, Nancy Muldoon3, Dorothea McAreavey3, Julia B Purdy3, Rohan Hazra4, Colleen Hadigan2, Ahmed M Gharib1. 1. Biomedical and Metabolic Imaging Branch, National Institute of Diabetes and Digestive and Kidney Diseases. 2. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases. 3. Critical Care Medicine Department, Clinical Center. 4. Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Abstract
BACKGROUND: Individuals with long-term human immunodeficiency virus (HIV) infection are at risk for premature vasculopathy and cardiovascular disease (CVD). We evaluated coronary vessel wall thickening, coronary plaque, and epicardial fat in patients infected with HIV early in life compared with healthy controls. METHODS: This is a prospective cross-sectional study of 35 young adults who acquired HIV in early life and 11 healthy controls, free of CVD. Time resolved phase-sensitive dual inversion recovery black-blood vessel wall magnetic resonance imaging (TRAPD) was used to measure proximal right coronary artery (RCA) wall thickness, and multidetector computed tomography (CT) angiography was used to quantify coronary plaque and epicardial fat. RESULTS: RCA vessel wall thickness was significantly increased in HIV-infected patients compared with sex- and race-matched controls (1.32 ± 0.21 mm vs 1.09 ± 0.14 mm, P = .002). No subject had discrete plaque on CT sufficient to cause luminal narrowing, and plaque was not related to RCA wall thickness. In multivariate regression analyses, smoking pack-years (P = .004) and HIV infection (P = .007) were independently associated with thicker RCA vessel walls. Epicardial fat did not differ between groups. Among the HIV-infected group, duration of antiretroviral therapy (ART) (P = .02), duration of stavudine exposure (P < .01), low-density lipoprotein cholesterol (P = .04), and smoking pack-years (P < .01) were positively correlated with RCA wall thickness. CONCLUSIONS: This investigation provides evidence of subclinical coronary vascular disease among individuals infected with HIV in early life. Increased duration of ART, hyperlipidemia, and smoking contributed to proximal RCA thickening, independent of atherosclerotic plaque quantified by CT. These modifiable risk factors appear to influence early atherogenesis as measured by coronary wall thickness and may be important targets for CVD risk reduction. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.
BACKGROUND: Individuals with long-term human immunodeficiency virus (HIV) infection are at risk for premature vasculopathy and cardiovascular disease (CVD). We evaluated coronary vessel wall thickening, coronary plaque, and epicardial fat in patients infected with HIV early in life compared with healthy controls. METHODS: This is a prospective cross-sectional study of 35 young adults who acquired HIV in early life and 11 healthy controls, free of CVD. Time resolved phase-sensitive dual inversion recovery black-blood vessel wall magnetic resonance imaging (TRAPD) was used to measure proximal right coronary artery (RCA) wall thickness, and multidetector computed tomography (CT) angiography was used to quantify coronary plaque and epicardial fat. RESULTS:RCA vessel wall thickness was significantly increased in HIV-infectedpatients compared with sex- and race-matched controls (1.32 ± 0.21 mm vs 1.09 ± 0.14 mm, P = .002). No subject had discrete plaque on CT sufficient to cause luminal narrowing, and plaque was not related to RCA wall thickness. In multivariate regression analyses, smoking pack-years (P = .004) and HIV infection (P = .007) were independently associated with thicker RCA vessel walls. Epicardial fat did not differ between groups. Among the HIV-infected group, duration of antiretroviral therapy (ART) (P = .02), duration of stavudine exposure (P < .01), low-density lipoprotein cholesterol (P = .04), and smoking pack-years (P < .01) were positively correlated with RCA wall thickness. CONCLUSIONS: This investigation provides evidence of subclinical coronary vascular disease among individuals infected with HIV in early life. Increased duration of ART, hyperlipidemia, and smoking contributed to proximal RCA thickening, independent of atherosclerotic plaque quantified by CT. These modifiable risk factors appear to influence early atherogenesis as measured by coronary wall thickness and may be important targets for CVD risk reduction. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.
Authors: Janet Lo; Suhny Abbara; Leon Shturman; Anand Soni; Jeffrey Wei; Jose A Rocha-Filho; Khurram Nasir; Steven K Grinspoon Journal: AIDS Date: 2010-01-16 Impact factor: 4.177
Authors: Ahmed M Gharib; Roderic I Pettigrew; Abdalla Elagha; Amy Hsu; Pam Welch; Steven M Holland; Alexandra F Freeman Journal: AJR Am J Roentgenol Date: 2009-12 Impact factor: 3.959
Authors: Grace A McComsey; Maryann O'Riordan; Stanley L Hazen; Dalia El-Bejjani; Shweta Bhatt; Marie-Luise Brennan; Norma Storer; Jerome Adell; Dean A Nakamoto; Vikram Dogra Journal: AIDS Date: 2007-05-11 Impact factor: 4.177
Authors: Cuilian Miao; Shaoguang Chen; Robson Macedo; Shenghan Lai; Kiang Liu; Debiao Li; Bruce A Wasserman; Jens Vogel-Claussen; Jens Vogel-Clausen; João A C Lima; David A Bluemke Journal: J Am Coll Cardiol Date: 2009-05-05 Impact factor: 24.094
Authors: Frank J Rybicki; Hansel J Otero; Michael L Steigner; Gabriel Vorobiof; Leelakrishna Nallamshetty; Dimitrios Mitsouras; Hale Ersoy; Richard T Mather; Philip F Judy; Tianxi Cai; Karl Coyner; Kurt Schultz; Amanda G Whitmore; Marcelo F Di Carli Journal: Int J Cardiovasc Imaging Date: 2008-03-27 Impact factor: 2.357
Authors: Nina Friis-Møller; Peter Reiss; Caroline A Sabin; Rainer Weber; Antonella d'Arminio Monforte; Wafaa El-Sadr; Rodolphe Thiébaut; Stephane De Wit; Ole Kirk; Eric Fontas; Matthew G Law; Andrew Phillips; Jens D Lundgren Journal: N Engl J Med Date: 2007-04-26 Impact factor: 91.245
Authors: James K Min; Leslee J Shaw; Richard B Devereux; Peter M Okin; Jonathan W Weinsaft; Donald J Russo; Nicholas J Lippolis; Daniel S Berman; Tracy Q Callister Journal: J Am Coll Cardiol Date: 2007-09-04 Impact factor: 24.094
Authors: Hasina Samji; Angela Cescon; Robert S Hogg; Sharada P Modur; Keri N Althoff; Kate Buchacz; Ann N Burchell; Mardge Cohen; Kelly A Gebo; M John Gill; Amy Justice; Gregory Kirk; Marina B Klein; P Todd Korthuis; Jeff Martin; Sonia Napravnik; Sean B Rourke; Timothy R Sterling; Michael J Silverberg; Stephen Deeks; Lisa P Jacobson; Ronald J Bosch; Mari M Kitahata; James J Goedert; Richard Moore; Stephen J Gange Journal: PLoS One Date: 2013-12-18 Impact factor: 3.240
Authors: Aviva S Mattingly; Aylin B Unsal; Julia B Purdy; Ahmed M Gharib; Adam Rupert; Joseph A Kovacs; Dorothea McAreavey; Rohan Hazra; Khaled Z Abd-Elmoniem; Colleen Hadigan Journal: Pediatr Infect Dis J Date: 2017-01 Impact factor: 2.129
Authors: Allison R Kirkpatrick; Aylin B Unsal; Joel N Blankson; Richard D Moore; Thomas C Quinn; Colleen Hadigan; Oliver Laeyendecker Journal: Pediatr Infect Dis J Date: 2017-11 Impact factor: 2.129
Authors: Khaled Z Abd-Elmoniem; Nadine Ramos; Saami K Yazdani; Ahmed M Ghanem; Steven M Holland; Alexandra F Freeman; Ahmed M Gharib Journal: Atherosclerosis Date: 2017-01-19 Impact factor: 5.162
Authors: Ahmed M Ghanem; Jatin Raj Matta; Reham Elgarf; Ahmed Hamimi; Ranganath Muniyappa; Hadjira Ishaq; Colleen Hadigan; Michael V McConnell; Ahmed M Gharib; Khaled Z Abd-Elmoniem Journal: Radiol Cardiothorac Imaging Date: 2019-04-25