Literature DB >> 25155386

Substituted dithiazole piperazine benzamides as novel amyloid beta peptide reducing agents.

Hongjie Wang1, Ruizhi Wang1, Madepalli K Lakshmana1, Adel Nefzi2.   

Abstract

Alzheimer's disease is a persistent neurodegenerative disorder of elderly characterized clinically by irreversible loss of memory due to accumulation of amyloid beta peptides within the amyloid plaques. We report the parallel synthesis and screening results of diverse substituted di-thiazole piperazine benzamides. A new compound TPI-1917-49 was identified as a promising amyloid reducing agent by lowering the levels of Aβ at least in two cell types and in vivo.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Alzheimer’s disease; Amyloid reducing agent; Parallel synthesis; Thiazole

Mesh：

Substances：

Year:  2014        PMID： 25155386      PMCID： PMC4311522          DOI： 10.1016/j.bmcl.2014.08.022

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

1.  sAPP as a regulator of dendrite motility and melanin release in epidermal melanocytes and melanoma cells.

Authors:  Thomas Quast; Sven Wehner; Gregor Kirfel; Klaus Jaeger; Michele De Luca; Volker Herzog
Journal:  FASEB J       Date:  2003-07-03       Impact factor: 5.191

Review 2.  Traumatic brain injury and amyloid-β pathology: a link to Alzheimer's disease?

Authors:  Victoria E Johnson; William Stewart; Douglas H Smith
Journal:  Nat Rev Neurosci       Date:  2010-05       Impact factor: 34.870

3.  Mechanism of thioflavin T binding to amyloid fibrils.

Authors:  Ritu Khurana; Chris Coleman; Cristian Ionescu-Zanetti; Sue A Carter; Vinay Krishna; Rajesh K Grover; Raja Roy; Shashi Singh
Journal:  J Struct Biol       Date:  2005-09       Impact factor: 2.867

4.  Clubbed thiazoles by MAOS: a novel approach to cyclin-dependent kinase 5/p25 inhibitors as a potential treatment for Alzheimer's disease.

Authors:  Mahendra Ramesh Shiradkar; Kalyan Chakravarthy Akula; Varaprasad Dasari; Vijayakumar Baru; Bhoomeshwar Chiningiri; Santosh Gandhi; Ranjit Kaur
Journal:  Bioorg Med Chem       Date:  2007-01-30       Impact factor: 3.641

Review 5.  Beta-amyloid, blood vessels, and brain function.

Authors:  Eric E Smith; Steven M Greenberg
Journal:  Stroke       Date:  2009-05-14       Impact factor: 7.914

6.  A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model.

Authors:  Rolf Postina; Anja Schroeder; Ilse Dewachter; Juergen Bohl; Ulrich Schmitt; Elzbieta Kojro; Claudia Prinzen; Kristina Endres; Christoph Hiemke; Manfred Blessing; Pascaline Flamez; Antoine Dequenne; Emile Godaux; Fred van Leuven; Falk Fahrenholz
Journal:  J Clin Invest       Date:  2004-05       Impact factor: 14.808

7.  Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor.

Authors:  J M Roch; E Masliah; A C Roch-Levecq; M P Sundsmo; D A Otero; I Veinbergs; T Saitoh
Journal:  Proc Natl Acad Sci U S A       Date:  1994-08-02       Impact factor: 11.205

8.  Targeting amyloid-beta in glaucoma treatment.

Authors:  Li Guo; Thomas E Salt; Vy Luong; Nicholas Wood; William Cheung; Annelie Maass; Giulio Ferrari; Françoise Russo-Marie; Adam M Sillito; Michael E Cheetham; Stephen E Moss; Frederick W Fitzke; M Francesca Cordeiro
Journal:  Proc Natl Acad Sci U S A       Date:  2007-08-07       Impact factor: 11.205

9.  Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway.

Authors:  Nidhi Gakhar-Koppole; Phillip Hundeshagen; Claudia Mandl; Sascha W Weyer; Bernadette Allinquant; Ulrike Müller; Francesca Ciccolini
Journal:  Eur J Neurosci       Date:  2008-08-20       Impact factor: 3.386

10.  A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation.

Authors:  Madepalli K Lakshmana; John Y Chung; Supul Wickramarachchi; Eileen Tak; Elisabetta Bianchi; Edward H Koo; David E Kang
Journal:  FASEB J       Date:  2009-09-03       Impact factor: 5.191
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.