| Literature DB >> 17291769 |
Mahendra Ramesh Shiradkar1, Kalyan Chakravarthy Akula, Varaprasad Dasari, Vijayakumar Baru, Bhoomeshwar Chiningiri, Santosh Gandhi, Ranjit Kaur.
Abstract
A novel clubbed triazolyl thiazole series of cdk5/p25 inhibitors, potentially useful for the treatment of Alzheimer's disease, is disclosed. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain cdk5/p25 and thus have potential as possible treatments for Alzheimer's disease.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17291769 DOI： 10.1016/j.bmc.2007.01.043
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641