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Literature DB >> 25154606

Taming the young and restless--epigenetic gene regulation in pancreas and beta-cell precursors.

Abstract

The in vivo assessment of epigenetic changes during mouse pancreatic beta‐cell differentiation reveals surprising differences to directed, in vitro differentiation of human embryonic stem cells. New findings reported in this issue of The EMBO Journal further identify Ezh2 as a critical determinant of endocrine progenitor number and could instruct improved protocols for stem cell-based therapies.

Entities: Disease Gene Species

Mesh：

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Year: 2014 PMID： 25154606 PMCID： PMC4282500 DOI： 10.15252/embj.201489751

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

7 in total

1. Chromatin "prepattern" and histone modifiers in a fate choice for liver and pancreas.

Authors: Cheng-Ran Xu; Philip A Cole; David J Meyers; Jay Kormish; Sharon Dent; Kenneth S Zaret
Journal: Science Date: 2011-05-20 Impact factor: 47.728

2. Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells.

Authors: Ruiyu Xie; Logan J Everett; Hee-Woong Lim; Nisha A Patel; Jonathan Schug; Evert Kroon; Olivia G Kelly; Allen Wang; Kevin A D'Amour; Allan J Robins; Kyoung-Jae Won; Klaus H Kaestner; Maike Sander
Journal: Cell Stem Cell Date: 2013-01-11 Impact factor: 24.633

3. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.

Authors: Julie B Sneddon; Malgorzata Borowiak; Douglas A Melton
Journal: Nature Date: 2012-10-07 Impact factor: 49.962

4. Dynamics of genomic H3K27me3 domains and role of EZH2 during pancreatic endocrine specification.

Authors: Cheng-Ran Xu; Lin-Chen Li; Greg Donahue; Lei Ying; Yu-Wei Zhang; Paul Gadue; Kenneth S Zaret
Journal: EMBO J Date: 2014-08-08 Impact factor: 11.598

5. Pancreatic mesenchyme regulates epithelial organogenesis throughout development.

Authors: Limor Landsman; Amar Nijagal; Theresa J Whitchurch; Renee L Vanderlaan; Warren E Zimmer; Tippi C Mackenzie; Matthias Hebrok
Journal: PLoS Biol Date: 2011-09-06 Impact factor: 8.029

6. A scalable system for production of functional pancreatic progenitors from human embryonic stem cells.

Authors: Thomas C Schulz; Holly Y Young; Alan D Agulnick; M Josephine Babin; Emmanuel E Baetge; Anne G Bang; Anindita Bhoumik; Igor Cepa; Rosemary M Cesario; Carl Haakmeester; Kuniko Kadoya; Jonathan R Kelly; Justin Kerr; Laura A Martinson; Amanda B McLean; Mark A Moorman; Janice K Payne; Mike Richardson; Kelly G Ross; Eric S Sherrer; Xuehong Song; Alistair Z Wilson; Eugene P Brandon; Chad E Green; Evert J Kroon; Olivia G Kelly; Kevin A D'Amour; Allan J Robins
Journal: PLoS One Date: 2012-05-18 Impact factor: 3.240

7. Factors expressed by murine embryonic pancreatic mesenchyme enhance generation of insulin-producing cells from hESCs.

Authors: Tingxia Guo; Limor Landsman; Na Li; Matthias Hebrok
Journal: Diabetes Date: 2013-01-10 Impact factor: 9.461

7 in total

3 in total