Marco Daperno1, Michele Comberlato2, Fabrizio Bossa3, Livia Biancone4, Andrea G Bonanomi5, Andrea Cassinotti6, Rocco Cosintino7, Giovanni Lombardi8, Roberto Mangiarotti7, Alfredo Papa9, Roberta Pica10, Fernando Rizzello11, Renata D'Incà12, Ambrogio Orlando13. 1. Gastroenterology Unit, Mauriziano Hospital Turin, Italy. Electronic address: mdaperno@teletu.it. 2. Bolzano Hospital, Bolzano, Italy. 3. Cancer Research and Cure Institute "Casa Sollievo Sofferenza", San Giovanni Rotondo (FG), Italy. 4. University Tor Vergata, Rome, Italy. 5. University Hospital "Careggi", Florence, Italy. 6. University Hospital "L. Sacco", Milan, Italy. 7. "San Camillo-Forlanini" Hospitals, Rome, Italy. 8. Hospital "Cardarelli", Naples, Italy. 9. Catholic University "S. Cuore", Columbus Integrated Complex, Rome, Italy. 10. "Sandro Pertini" Hospital, Rome, Italy. 11. University of Bologna, "S. Orsola Malpighi" Hospital, Bologna, Italy. 12. University of Padua, Padua, Italy. 13. United Hospitals "Villa Sofia-Cervello", Palermo, Italy.
Abstract
BACKGROUND: Endoscopic activity has become a therapeutic endpoint in inflammatory bowel disease. Aim of this study was to evaluate inter-observer agreement for endoscopic scores in a real-life setting. METHODS: 14 gastroenterologists with experience in inflammatory bowel disease care and endoscopic scoring reviewed videos of ulcerative colitis (n=13) and postoperative (n=10) and luminal (n=8) Crohn's disease. The Mayo subscore for ulcerative colitis, Rutgeerts score for postoperative Crohn's disease, Crohn's disease endoscopic index of severity (CDEIS), and the simple endoscopic score-Crohn's disease (SES-CD) for luminal Crohn's disease were calculated. A subset of five endoscopic clips were assessed by 30 general gastroenterologists without specific experience in endoscopic scores. Kappa statistics and intraclass correlation coefficients were used to measure agreement. RESULTS: Mayo subscore agreement was suboptimal: kappas were 0.53 (95% confidence interval 0.47-0.56) and 0.71 (0.67-0.76) for the two groups. Rutgeerts score agreement was fair: kappas were 0.57 (0.51-0.65) and 0.67 (0.60-0.72). Agreements for CDEIS and SES-CD were good: intraclass correlation coefficients for the two groups were 0.83 (0.54-1.00) and 0.67 (0.36-0.97) for CDEIS and 0.93 (0.76-1.00) and 0.68 (0.35-0.97) for SES-CD, respectively. CONCLUSION: The reproducibility of endoscopic scores in inflammatory bowel disease remains suboptimal, which could potentially have major effects on therapeutic choices.
BACKGROUND: Endoscopic activity has become a therapeutic endpoint in inflammatory bowel disease. Aim of this study was to evaluate inter-observer agreement for endoscopic scores in a real-life setting. METHODS: 14 gastroenterologists with experience in inflammatory bowel disease care and endoscopic scoring reviewed videos of ulcerative colitis (n=13) and postoperative (n=10) and luminal (n=8) Crohn's disease. The Mayo subscore for ulcerative colitis, Rutgeerts score for postoperative Crohn's disease, Crohn's disease endoscopic index of severity (CDEIS), and the simple endoscopic score-Crohn's disease (SES-CD) for luminal Crohn's disease were calculated. A subset of five endoscopic clips were assessed by 30 general gastroenterologists without specific experience in endoscopic scores. Kappa statistics and intraclass correlation coefficients were used to measure agreement. RESULTS:Mayo subscore agreement was suboptimal: kappas were 0.53 (95% confidence interval 0.47-0.56) and 0.71 (0.67-0.76) for the two groups. Rutgeerts score agreement was fair: kappas were 0.57 (0.51-0.65) and 0.67 (0.60-0.72). Agreements for CDEIS and SES-CD were good: intraclass correlation coefficients for the two groups were 0.83 (0.54-1.00) and 0.67 (0.36-0.97) for CDEIS and 0.93 (0.76-1.00) and 0.68 (0.35-0.97) for SES-CD, respectively. CONCLUSION: The reproducibility of endoscopic scores in inflammatory bowel disease remains suboptimal, which could potentially have major effects on therapeutic choices.
Authors: Joana Roseira; Ana Rita Ventosa; Helena Tavares de Sousa; Jorge Brito Journal: United European Gastroenterol J Date: 2020-07-14 Impact factor: 4.623
Authors: Robert Battat; Parambir S Dulai; Christopher Ma; Vipul Jairath; Brian G Feagan; William J Sandborn; Reena Khanna Journal: Curr Treat Options Gastroenterol Date: 2020-01-04
Authors: Reena Khanna; Sigrid A Nelson; Brian G Feagan; Geert D'Haens; William J Sandborn; G Y Zou; John K MacDonald; Claire E Parker; Vipul Jairath; Barrett G Levesque Journal: Cochrane Database Syst Rev Date: 2016-08-08