Raymond Javan Chan1, Jennifer Mann2, Lee Tripcony2, Jacqui Keller2, Robyn Cheuk2, Rae Blades2, Samantha Keogh3, Christopher Poole4, Christopher Walsh2. 1. Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia; School of Nursing, Queensland University of Technology, Kelvin Grove, Australia; Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Australia. Electronic address: email.rchan@gmail.com. 2. Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia. 3. National Health and Medical Research Council Centre for Research Excellence in Nursing, Centre for Health Practice Innovation-Griffith Health Institute, Griffith University, Nathan, Australia. 4. Cancer Care Services, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia; Science and Engineering Faculty, Queensland University of Technology, Brisbane, Australia.
Abstract
PURPOSE: To investigate the effects of a natural oil-based emulsion containing allantoin versus aqueous cream for preventing and managing radiation-induced skin reactions. METHODS AND MATERIALS: A total of 174 patients were randomized and participated in the study. Patients received either cream 1 (the natural oil-based emulsion containing allantoin) or cream 2 (aqueous cream). Skin toxicity, pain, itching, and skin-related quality of life scores were collected for up to 4 weeks after radiation treatment. RESULTS: Patients who received cream 1 had a significantly lower average level of Common Terminology Criteria for Adverse Events at week 3 (P<.05) but had statistically higher average levels of skin toxicity at weeks 7, 8, and 9 (all P<.001). Similar results were observed when skin toxicity was analyzed by grades. With regards to pain, patients in the cream 2 group had a significantly higher average level of worst pain (P<.05) and itching (P=.046) compared with the cream 1 group at week 3; however, these differences were not observed at other weeks. In addition, there was a strong trend for cream 2 to reduce the incidence of grade 2 or more skin toxicity in comparison with cream 1 (P=.056). Overall, more participants in the cream 1 group were required to use another topical treatment at weeks 8 (P=.049) and 9 (P=.01). CONCLUSION: The natural oil-based emulsion containing allantoin seems to have similar effects for managing skin toxicity compared with aqueous cream up to week 5; however, it becomes significantly less effective at later weeks into the radiation treatment and beyond treatment completion (week 6 and beyond). There were no major differences in pain, itching, and skin-related quality of life. In light of these results, clinicians and patients can base their decision on costs and preferences. Overall, aqueous cream seems to be a more preferred option. Crown
RCT Entities:
PURPOSE: To investigate the effects of a natural oil-based emulsion containing allantoin versus aqueous cream for preventing and managing radiation-induced skin reactions. METHODS AND MATERIALS: A total of 174 patients were randomized and participated in the study. Patients received either cream 1 (the natural oil-based emulsion containing allantoin) or cream 2 (aqueous cream). Skin toxicity, pain, itching, and skin-related quality of life scores were collected for up to 4 weeks after radiation treatment. RESULTS:Patients who received cream 1 had a significantly lower average level of Common Terminology Criteria for Adverse Events at week 3 (P<.05) but had statistically higher average levels of skin toxicity at weeks 7, 8, and 9 (all P<.001). Similar results were observed when skin toxicity was analyzed by grades. With regards to pain, patients in the cream 2 group had a significantly higher average level of worst pain (P<.05) and itching (P=.046) compared with the cream 1 group at week 3; however, these differences were not observed at other weeks. In addition, there was a strong trend for cream 2 to reduce the incidence of grade 2 or more skin toxicity in comparison with cream 1 (P=.056). Overall, more participants in the cream 1 group were required to use another topical treatment at weeks 8 (P=.049) and 9 (P=.01). CONCLUSION: The natural oil-based emulsion containing allantoin seems to have similar effects for managing skin toxicity compared with aqueous cream up to week 5; however, it becomes significantly less effective at later weeks into the radiation treatment and beyond treatment completion (week 6 and beyond). There were no major differences in pain, itching, and skin-related quality of life. In light of these results, clinicians and patients can base their decision on costs and preferences. Overall, aqueous cream seems to be a more preferred option. Crown
Authors: Elaine Barros Ferreira; Christiane Inocêncio Vasques; Rafael Gadia; Raymond Javan Chan; Eliete Neves Silva Guerra; Luis André Mezzomo; Graziela De Luca Canto; Paula Elaine Diniz Dos Reis Journal: Support Care Cancer Date: 2016-12-12 Impact factor: 3.603
Authors: Gabriela Näf; Urs E Gasser; Hans E Holzgang; Sandra Schafroth; Christoph Oehler; Daniel R Zwahlen Journal: Int J Breast Cancer Date: 2018-07-02